Aspartate Carbamoyltransferase
"Aspartate Carbamoyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.
| Descriptor ID |
D001221
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| MeSH Number(s) |
D08.811.641.500 D08.811.913.555.275.200
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Aspartate Carbamoyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Aspartate Carbamoyltransferase".
This graph shows the total number of publications written about "Aspartate Carbamoyltransferase" by people in this website by year, and whether "Aspartate Carbamoyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Aspartate Carbamoyltransferase" by people in Profiles.
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Cell-based analysis of CAD variants identifies individuals likely to benefit from uridine therapy. Genet Med. 2020 10; 22(10):1598-1605.
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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures. Cell. 2018 09 06; 174(6):1559-1570.e22.
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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. Nature. 2015 Nov 19; 527(7578):379-383.
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Modeling macromolecular motions by x-ray-scattering-constrained molecular dynamics. Biophys J. 2015 May 19; 108(10):2421-2423.
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Interaction of heat shock protein 90 and the co-chaperone Cpr6 with Ura2, a bifunctional enzyme required for pyrimidine biosynthesis. J Biol Chem. 2013 Sep 20; 288(38):27406-27414.
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The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells. Gastroenterology. 2012 Jun; 142(7):1483-92.e6.
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Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax. Oncogene. 2002 Oct 17; 21(47):7230-4.
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Caspase-3-dependent and -independent apoptosis in focal brain ischemia. Mol Med. 2002 Jul; 8(7):347-52.
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Aspartate carbamoyltransferase activity, drug concentrations, and pyrimidine nucleotides in tissue from patients treated with N-(phosphonacetyl)-L-aspartate. Biochem Pharmacol. 1982 Oct 15; 31(20):3317-21.