Lactase-Phlorizin Hydrolase
"Lactase-Phlorizin Hydrolase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. The second domain (EC 3.2.1.108) hydrolyzes LACTOSE and is found in the intestinal brush border membrane. Loss of activity for this enzyme in humans results in LACTOSE INTOLERANCE.
| Descriptor ID |
D010694
|
| MeSH Number(s) |
D08.811.277.450.410.100.500.500 D08.811.277.450.420.475 D08.811.641.761
|
| Concept/Terms |
Lactase-Phlorizin Hydrolase- Lactase-Phlorizin Hydrolase
- Hydrolase, Lactase-Phlorizin
- Lactase Phlorizin Hydrolase
- Glycosylceramidase
- Phloretin-Glucosidase
- Phloretin Glucosidase
- Phlorizin Hydrolase
- Hydrolase, Phlorizin
- Glycosyl Ceramidase
- Ceramidase, Glycosyl
- Lactase-Glycosylceramidase
- Lactase Glycosylceramidase
|
Below are MeSH descriptors whose meaning is more general than "Lactase-Phlorizin Hydrolase".
Below are MeSH descriptors whose meaning is more specific than "Lactase-Phlorizin Hydrolase".
This graph shows the total number of publications written about "Lactase-Phlorizin Hydrolase" by people in this website by year, and whether "Lactase-Phlorizin Hydrolase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 2 | 0 | 2 |
| 2001 | 2 | 1 | 3 |
| 2002 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lactase-Phlorizin Hydrolase" by people in Profiles.
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A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. Mol Pharm. 2012 Nov 05; 9(11):3246-58.
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Role of intestinal hydrolase in the absorption of prenylated flavonoids present in Yinyanghuo. Molecules. 2011 Feb 01; 16(2):1336-48.
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An NSP4-dependant mechanism by which rotavirus impairs lactase enzymatic activity in brush border of human enterocyte-like Caco-2 cells. Cell Microbiol. 2007 Sep; 9(9):2254-66.
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Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs. J Nutr. 2002 Sep; 132(9):2673-81.
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Oral IGF-I alters the posttranslational processing but not the activity of lactase-phlorizin hydrolase in formula-fed neonatal pigs. J Nutr. 2001 Sep; 131(9):2235-41.
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Intestinal protein and LPH synthesis in parenterally fed piglets receiving partial enteral nutrition and enteral insulinlike growth factor 1. J Pediatr Gastroenterol Nutr. 2001 Aug; 33(2):189-95.
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Developmental regulation of intestinal epithelial hydrolase activity in human fetal jejunal xenografts maintained in severe-combined immunodeficient mice. Pediatr Res. 2001 Aug; 50(2):196-202.
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Protein kinetics determined in vivo with a multiple-tracer, single-sample protocol: application to lactase synthesis. Am J Physiol. 1998 03; 274(3):G591-8.
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Parenteral nutrition selectively decreases protein synthesis in the small intestine. Am J Physiol. 1998 01; 274(1):G131-7.
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Lactase phlorizin hydrolase synthesis is decreased in protein-malnourished pigs. J Nutr. 1997 May; 127(5):687-93.