Ornithine Carbamoyltransferase
"Ornithine Carbamoyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) from CARBAMOYL PHOSPHATE and L-ornithine (ORNITHINE). Deficiency of this enzyme may be transmitted as an X-linked trait. EC 2.1.3.3.
| Descriptor ID |
D009954
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| MeSH Number(s) |
D08.811.913.555.275.600
|
| Concept/Terms |
Ornithine Carbamoyltransferase- Ornithine Carbamoyltransferase
- Carbamoyltransferase, Ornithine
- Ornithine Transcarbamylase
- Transcarbamylase, Ornithine
- Ornithine Carbamylphosphate Transferase
- Carbamylphosphate Transferase, Ornithine
- Transferase, Ornithine Carbamylphosphate
|
Below are MeSH descriptors whose meaning is more general than "Ornithine Carbamoyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Ornithine Carbamoyltransferase".
This graph shows the total number of publications written about "Ornithine Carbamoyltransferase" by people in this website by year, and whether "Ornithine Carbamoyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Ornithine Carbamoyltransferase" by people in Profiles.
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Ex Vivo Enteroids Recapitulate In Vivo Citrulline Production in Mice. J Nutr. 2018 09 01; 148(9):1415-1420.
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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures. Cell. 2018 09 06; 174(6):1559-1570.e22.
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Dietary arginine requirements for growth are dependent on the rate of citrulline production in mice. J Nutr. 2015 Jun; 145(6):1227-31.
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Vector sequences are not detected in tumor tissue from research subjects with ornithine transcarbamylase deficiency who previously received adenovirus gene transfer. Hum Gene Ther. 2013 Sep; 24(9):814-9.
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Phenotypic correction of ornithine transcarbamylase deficiency using low dose helper-dependent adenoviral vectors. J Gene Med. 2008 Aug; 10(8):890-6.
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Utility of oligonucleotide array-based comparative genomic hybridization for detection of target gene deletions. Clin Chem. 2008 Jul; 54(7):1141-8.
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Interaction between murine spf-ash mutation and genetic background yields different metabolic phenotypes. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1764-71.
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Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) mice. J Nutr. 2006 Jul; 136(7):1834-8.
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Reduced ornithine transcarbamylase activity does not impair ureagenesis in Otc(spf-ash) mice. J Nutr. 2006 Apr; 136(4):1017-20.
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Long-term correction of ornithine transcarbamylase deficiency by WPRE-mediated overexpression using a helper-dependent adenovirus. Mol Ther. 2004 Sep; 10(3):492-9.