DNA-(Apurinic or Apyrimidinic Site) Lyase
"DNA-(Apurinic or Apyrimidinic Site) Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
| Descriptor ID |
D043603
|
| MeSH Number(s) |
D08.811.074.750 D08.811.520.241.225
|
| Concept/Terms |
DNA-(Apurinic or Apyrimidinic Site) Lyase- DNA-(Apurinic or Apyrimidinic Site) Lyase
- AP Endonuclease
- Endonuclease, AP
- Endodeoxyribonuclease (Apurinic or Apyrimidinic)
- Apurine-Apyrimidine Endonuclease
- Apurine Apyrimidine Endonuclease
- Endonuclease, Apurine-Apyrimidine
- Apurinic DNA Endonuclease
- DNA Endonuclease, Apurinic
- Endonuclease, Apurinic DNA
- Apurinic Endonuclease
- Endonuclease, Apurinic
- DNA Lyase (Apurinic or Apyrimidinic)
- AP Lyase
|
Below are MeSH descriptors whose meaning is more general than "DNA-(Apurinic or Apyrimidinic Site) Lyase".
Below are MeSH descriptors whose meaning is more specific than "DNA-(Apurinic or Apyrimidinic Site) Lyase".
This graph shows the total number of publications written about "DNA-(Apurinic or Apyrimidinic Site) Lyase" by people in this website by year, and whether "DNA-(Apurinic or Apyrimidinic Site) Lyase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 2 | 0 | 2 |
| 2008 | 2 | 0 | 2 |
| 2009 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA-(Apurinic or Apyrimidinic Site) Lyase" by people in Profiles.
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The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection. Nat Commun. 2023 12 09; 14(1):8169.
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Atlas of Subcellular RNA Localization Revealed by APEX-Seq. Cell. 2019 07 11; 178(2):473-490.e26.
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Comprehensive Profiling of DNA Repair Defects in Breast Cancer Identifies a Novel Class of Endocrine Therapy Resistance Drivers. Clin Cancer Res. 2018 10 01; 24(19):4887-4899.
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Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Gu?rin. PLoS One. 2012; 7(6):e38533.
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Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. Int J Radiat Oncol Biol Phys. 2011 Nov 01; 81(3):e67-73.
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Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility. FASEB J. 2009 Oct; 23(10):3459-69.
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Association and interactions between DNA repair gene polymorphisms and adult glioma. Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18(1):204-14.
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Long patch base excision repair in mammalian mitochondrial genomes. J Biol Chem. 2008 Sep 26; 283(39):26349-56.
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Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx. Clin Cancer Res. 2008 Jul 01; 14(13):4345-52.
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Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1. J Mol Biol. 2008 May 23; 379(1):28-37.