"Phosphofructokinase-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.
| Descriptor ID |
D010732
|
| MeSH Number(s) |
D08.811.913.696.620.225.850.500
|
| Concept/Terms |
Phosphofructokinase-1- Phosphofructokinase-1
- Phosphofructokinase 1
- 6-Phosphofructokinase
- 6 Phosphofructokinase
- Fructose-6-phosphate 1-Phosphotransferase
- 6-Phosphofructo-1-kinase
- Fructose-6-P 1-Kinase
|
Below are MeSH descriptors whose meaning is more general than "Phosphofructokinase-1".
Below are MeSH descriptors whose meaning is more specific than "Phosphofructokinase-1".
This graph shows the total number of publications written about "Phosphofructokinase-1" by people in this website by year, and whether "Phosphofructokinase-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphofructokinase-1" by people in Profiles.
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A mechanistic modeling framework reveals the key principles underlying tumor metabolism. PLoS Comput Biol. 2022 02; 18(2):e1009841.
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Copy number variation as a genetic basis for heterotaxy and heterotaxy-spectrum congenital heart defects. Philos Trans R Soc Lond B Biol Sci. 2016 12 19; 371(1710).
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Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun. 2010 May 07; 395(3):395-400.
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Human 6-phosphofructo-1-kinase gene has an additional intron upstream of start codon. Gene. 1989 Mar 15; 76(1):167-9.
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Site-directed mutagenesis in Bacillus stearothermophilus fructose-6-phosphate 1-kinase. Mutation at the substrate-binding site affects allosteric behavior. J Biol Chem. 1989 Jan 05; 264(1):131-5.
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Site-directed mutagenesis at the regulatory site of fructose 6-phosphate-1-kinase from Bacillus stearothermophilus. Biochem Biophys Res Commun. 1988 Oct 14; 156(1):537-42.
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High-level expression of Bacillus stearothermophilus 6-phosphofructo-1-kinase in Escherichia coli. Gene. 1987; 59(2-3):279-83.
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Different modes of interaction of calmodulin with its target enzymes. J Cardiovasc Pharmacol. 1986; 8 Suppl 8:S52-6.
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Carbohydrate interconversions and energy production. Circulation. 1985 Nov; 72(5 Pt 2):IV1-8.
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Cardiovascular imaging: the biochemical basis. Hosp Pract (Off Ed). 1984 Jun; 19(6):137-41, 147-55.