Dual Specificity Phosphatase 6
"Dual Specificity Phosphatase 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES and is primarily localized to the CYTOSOL.
| Descriptor ID |
D054642
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| MeSH Number(s) |
D08.811.277.352.650.587.600 D08.811.277.352.650.625.225.600 D08.811.277.352.650.775.250.600 D08.811.641.755.600 D12.644.360.268.600 D12.644.360.445.600 D12.776.476.268.600 D12.776.476.445.600
|
| Concept/Terms |
Dual Specificity Phosphatase 6- Dual Specificity Phosphatase 6
- Dual Specificity Protein Phosphatase 6
- MKP-3 Phosphatase
- MKP 3 Phosphatase
- Phosphatase, MKP-3
- MKP3 Phosphatase
- Phosphatase, MKP3
- MAP Kinase Phosphatase 3
- Mitogen-Activated Protein Kinase Phosphatase 3
- Mitogen Activated Protein Kinase Phosphatase 3
|
Below are MeSH descriptors whose meaning is more general than "Dual Specificity Phosphatase 6".
Below are MeSH descriptors whose meaning is more specific than "Dual Specificity Phosphatase 6".
This graph shows the total number of publications written about "Dual Specificity Phosphatase 6" by people in this website by year, and whether "Dual Specificity Phosphatase 6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dual Specificity Phosphatase 6" by people in Profiles.
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DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation. Proc Natl Acad Sci U S A. 2018 08 21; 115(34):E8027-E8036.
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Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors. Bioorg Med Chem Lett. 2017 12 15; 27(24):5473-5480.
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Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer Cell. 2015 Jul 13; 28(1):114-28.
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DUSP6 is a novel transcriptional target of p53 and regulates p53-mediated apoptosis by modulating expression levels of Bcl-2 family proteins. FEBS Lett. 2012 Nov 30; 586(23):4233-40.
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MAP kinase phosphatase activity sets the threshold for thymocyte positive selection. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16257-62.
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Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance. Cancer Res. 2006 Jun 01; 66(11):5950-9.