Dual Specificity Phosphatase 1
"Dual Specificity Phosphatase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for P38 MITOGEN-ACTIVATED PROTEIN KINASES and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
| Descriptor ID |
D054638
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| MeSH Number(s) |
D08.811.277.352.650.587.200 D08.811.277.352.650.625.225.200 D08.811.277.352.650.775.250.200 D08.811.641.755.200 D12.644.360.268.200 D12.644.360.445.100 D12.776.476.268.200 D12.776.476.445.200
|
| Concept/Terms |
Dual Specificity Phosphatase 1- Dual Specificity Phosphatase 1
- CL100 Phosphatase
- Phosphatase, CL100
- Externally Regulated Phosphatase (ERP)
- MKP-1 Phosphatase
- MKP 1 Phosphatase
- Phosphatase, MKP-1
- MAP Phosphatase-1
- MAP Phosphatase 1
- Phosphatase-1, MAP
- MAPK Phosphatase
- Phosphatase, MAPK
- Mitogen-Activated Protein Phosphatase-1
- Mitogen Activated Protein Phosphatase 1
- Phosphatase-1, Mitogen-Activated Protein
- Protein Phosphatase-1, Mitogen-Activated
- 3CH134 Phosphatase
- Phosphatase, 3CH134
- Map Kinase Phosphatase 1
|
Below are MeSH descriptors whose meaning is more general than "Dual Specificity Phosphatase 1".
Below are MeSH descriptors whose meaning is more specific than "Dual Specificity Phosphatase 1".
This graph shows the total number of publications written about "Dual Specificity Phosphatase 1" by people in this website by year, and whether "Dual Specificity Phosphatase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dual Specificity Phosphatase 1" by people in Profiles.
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Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma in a Taiwanese Population. Clin Cancer Res. 2016 07 01; 22(13):3340-7.
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Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer. Clin Cancer Res. 2016 Apr 01; 22(7):1713-24.
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Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates. Immunity. 2011 Jul 22; 35(1):45-58.
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MKP-1 is necessary for T cell activation and function. J Biol Chem. 2009 Nov 06; 284(45):30815-24.
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Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1. J Biol Chem. 2009 Oct 02; 284(40):27123-34.
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Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes. Mol Cell Biol. 2008 Sep; 28(18):5785-94.
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Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance. Cancer Res. 2007 May 01; 67(9):4459-66.
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Proteasome inhibitors induce a p38 mitogen-activated protein kinase (MAPK)-dependent anti-apoptotic program involving MAPK phosphatase-1 and Akt in models of breast cancer. Breast Cancer Res Treat. 2006 Nov; 100(1):33-47.
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Evidence that mitogen-activated protein kinase phosphatase-1 induction by proteasome inhibitors plays an antiapoptotic role. Mol Pharmacol. 2004 Dec; 66(6):1478-90.
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Repression of mitogen-activated protein kinase (MAPK) phosphatase-1 by anthracyclines contributes to their antiapoptotic activation of p44/42-MAPK. J Pharmacol Exp Ther. 2003 Dec; 307(3):861-9.