"Gene Products, vpr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Trans-acting proteins which accelerate retroviral virus replication. The vpr proteins act in trans to increase the levels of specified proteins. vpr is short for viral protein R, where R is undefined.
| Descriptor ID |
D016336
|
| MeSH Number(s) |
D12.776.964.925.984.430
|
| Concept/Terms |
Gene Products, vpr- Gene Products, vpr
- vpr Gene Products
- Viral Protein R (vpr)
- vpr Protein
- Viral Protein R
- Protein R, Viral
- Gene Product, vpr
- vpr Gene Product
|
Below are MeSH descriptors whose meaning is more general than "Gene Products, vpr".
Below are MeSH descriptors whose meaning is more specific than "Gene Products, vpr".
This graph shows the total number of publications written about "Gene Products, vpr" by people in this website by year, and whether "Gene Products, vpr" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 2 | 1 | 3 |
| 2005 | 2 | 0 | 2 |
| 2006 | 2 | 0 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gene Products, vpr" by people in Profiles.
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Tubular-specific expression of HIV protein Vpr leads to severe tubulointerstitial damage accompanied by progressive fibrosis and cystic development. Kidney Int. 2023 03; 103(3):529-543.
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HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRa and PPARa dysregulation: implications for HIV-specific pathogenesis of NAFLD. Sci Rep. 2017 10 17; 7(1):13362.
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HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation. Sci Transl Med. 2013 Nov 27; 5(213):213ra164.
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HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells. AIDS. 2010 May 15; 24(8):1107-19.
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HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells. AIDS. 2009 Sep 24; 23(15):2054-6.
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HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells. Kidney Int. 2008 Oct; 74(8):1049-58.
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The role of Vpr in HIV-1 disease progression is independent of its G2 arrest induction function. Cell Cycle. 2006 Oct; 5(19):2275-80.
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Effects of transgenic expression of HIV-1 Vpr on lipid and energy metabolism in mice. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E40-8.
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Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo. J Virol. 2005 Dec; 79(24):15443-51.
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ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. Cell Death Differ. 2005 Apr; 12(4):326-34.