TOR Serine-Threonine Kinases
"TOR Serine-Threonine Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that SIROLIMUS (commonly known as rapamycin) forms an inhibitory complex with TACROLIMUS BINDING PROTEIN 1A that blocks the action of its enzymatic activity.
| Descriptor ID |
D058570
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.931 D12.776.476.925
|
| Concept/Terms |
TOR Serine-Threonine Kinases- TOR Serine-Threonine Kinases
- Kinases, TOR Serine-Threonine
- Serine-Threonine Kinases, TOR
- TOR Serine Threonine Kinases
- Target of Rapamycin Proteins
- Rapamycin Proteins Target
- mTOR Serine-Threonine Kinases
- Kinases, mTOR Serine-Threonine
- Serine-Threonine Kinases, mTOR
- mTOR Serine Threonine Kinases
- Mechanistic Target of Rapamycin Protein
- FK506 Binding Protein 12-Rapamycin Associated Protein 1
- FK506 Binding Protein 12 Rapamycin Associated Protein 1
- TOR Kinases
- FKBP12-Rapamycin Associated Protein
- Associated Protein, FKBP12-Rapamycin
- FKBP12 Rapamycin Associated Protein
- Protein, FKBP12-Rapamycin Associated
- FKBP12-Rapamycin Complex-Associated Protein
- Complex-Associated Protein, FKBP12-Rapamycin
- FKBP12 Rapamycin Complex Associated Protein
- Protein, FKBP12-Rapamycin Complex-Associated
- RAFT-1 Protein
- Protein, RAFT-1
- RAFT 1 Protein
- Rapamycin Target Protein
- Protein, Rapamycin Target
- Target Protein, Rapamycin
- mTOR Protein
- Protein, mTOR
|
Below are MeSH descriptors whose meaning is more general than "TOR Serine-Threonine Kinases".
Below are MeSH descriptors whose meaning is more specific than "TOR Serine-Threonine Kinases".
This graph shows the total number of publications written about "TOR Serine-Threonine Kinases" by people in this website by year, and whether "TOR Serine-Threonine Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 4 | 4 |
| 2007 | 0 | 5 | 5 |
| 2008 | 0 | 14 | 14 |
| 2009 | 0 | 14 | 14 |
| 2010 | 8 | 15 | 23 |
| 2011 | 7 | 6 | 13 |
| 2012 | 14 | 7 | 21 |
| 2013 | 10 | 8 | 18 |
| 2014 | 4 | 11 | 15 |
| 2015 | 14 | 12 | 26 |
| 2016 | 15 | 19 | 34 |
| 2017 | 7 | 10 | 17 |
| 2018 | 4 | 9 | 13 |
| 2019 | 9 | 9 | 18 |
| 2020 | 2 | 6 | 8 |
| 2021 | 2 | 4 | 6 |
| 2022 | 0 | 8 | 8 |
| 2023 | 1 | 8 | 9 |
| 2024 | 3 | 3 | 6 |
| 2025 | 4 | 3 | 7 |
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Below are the most recent publications written about "TOR Serine-Threonine Kinases" by people in Profiles.
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Mammalian Target Rapamycin Inhibition as a Therapeutic Target for Prevention of Proliferative Vitreoretinopathy. JAMA Ophthalmol. 2025 Sep 01; 143(9):777-784.
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A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas. Nat Commun. 2025 Jul 31; 16(1):7018.
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A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase. Nat Commun. 2025 May 17; 16(1):4588.
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TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal Fibroblasts. Aging Cell. 2025 Jul; 24(7):e70083.
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Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis. EMBO J. 2025 Mar; 44(5):1414-1441.
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Glioma-induced alterations in excitatory neurons are reversed by mTOR inhibition. Neuron. 2025 Mar 19; 113(6):858-875.e10.
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Oral vancomycin treatment alters levels of indole derivatives and secondary bile acids modulating the expression of mTOR pathway genes in astrocytes during EAE. Brain Behav Immun. 2025 Mar; 125:355-370.
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Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil. Nucleic Acids Res. 2024 Nov 11; 52(20):12534-12548.
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MTOR maintains endothelial cell integrity to limit lung vascular injury. J Biol Chem. 2024 12; 300(12):107952.
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PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy. Diabetes. 2024 Nov 01; 73(11):1805-1820.