3-Phosphoinositide-Dependent Protein Kinases
"3-Phosphoinositide-Dependent Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the production of the SECOND MESSENGERS, phosphatidylinositol 3,4,-biphosphate (PtdIns(3,4)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).
| Descriptor ID |
D064413
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| MeSH Number(s) |
D08.811.913.696.620.682.700.745
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| Concept/Terms |
3-Phosphoinositide-Dependent Protein Kinases- 3-Phosphoinositide-Dependent Protein Kinases
- 3 Phosphoinositide Dependent Protein Kinases
- Kinases, 3-Phosphoinositide-Dependent Protein
- Protein Kinases, 3-Phosphoinositide-Dependent
- 3-Phosphoinositide-Dependent Protein Kinase
- 3 Phosphoinositide Dependent Protein Kinase
- Kinase, 3-Phosphoinositide-Dependent Protein
- Protein Kinase, 3-Phosphoinositide-Dependent
3-Phosphoinositide Dependent Protein Kinase-1- 3-Phosphoinositide Dependent Protein Kinase-1
- 3 Phosphoinositide Dependent Protein Kinase 1
- 3-Phosphoinositide-Dependent Protein Kinase-1
- Kinase-1, 3-Phosphoinositide-Dependent Protein
- Protein Kinase-1, 3-Phosphoinositide-Dependent
- PtdIns(3,4,5)P3-Dependent Protein Kinase-1
- 3-Phosphoinositide-Dependent Kinase 1 (PDK1)
3-Phosphoinositide Dependent Protein Kinase-2- 3-Phosphoinositide Dependent Protein Kinase-2
- 3 Phosphoinositide Dependent Protein Kinase 2
- 3-Phosphoinositide-Dependent Protein Kinase-2
- Kinase-2, 3-Phosphoinositide-Dependent Protein
- Protein Kinase-2, 3-Phosphoinositide-Dependent
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Below are MeSH descriptors whose meaning is more general than "3-Phosphoinositide-Dependent Protein Kinases".
Below are MeSH descriptors whose meaning is more specific than "3-Phosphoinositide-Dependent Protein Kinases".
This graph shows the total number of publications written about "3-Phosphoinositide-Dependent Protein Kinases" by people in this website by year, and whether "3-Phosphoinositide-Dependent Protein Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "3-Phosphoinositide-Dependent Protein Kinases" by people in Profiles.
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Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy. PLoS Biol. 2023 08; 21(8):e3002227.
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A new microdeletion syndrome involving TBC1D24, ATP6V0C, and PDPK1 causes epilepsy, microcephaly, and developmental delay. Genet Med. 2019 05; 21(5):1058-1064.
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Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. Elife. 2016 06 25; 5.
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Galanin-like peptide (GALP) neurone-specific phosphoinositide 3-kinase signalling regulates GALP mRNA levels in the hypothalamus of males and luteinising hormone levels in both sexes. J Neuroendocrinol. 2014 Jul; 26(7):426-38.
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PI3K/Akt pathway restricts epithelial adhesion of Dr + Escherichia coli by down-regulating the expression of decay accelerating factor. Exp Biol Med (Maywood). 2014 May; 239(5):581-94.
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Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar; 9(3):706-17.
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3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Res. 2009 Aug 01; 69(15):6299-306.
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Role of PDK1 in regulation of gastric acid secretion. Cell Physiol Biochem. 2008; 22(5-6):725-34.
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Forkhead protein FKHR and its phosphorylated form p-FKHR in human prostate cancer. Hum Pathol. 2007 Oct; 38(10):1501-7.
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Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J Biol Chem. 2006 Dec 29; 281(52):39897-906.