Proto-Oncogene Proteins c-bcr
"Proto-Oncogene Proteins c-bcr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
| Descriptor ID |
D051562
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| MeSH Number(s) |
D08.811.913.696.620.682.700.759 D12.644.360.325.300.099.500 D12.776.476.325.300.099.500 D12.776.624.664.700.171
|
| Concept/Terms |
Proto-Oncogene Proteins c-bcr- Proto-Oncogene Proteins c-bcr
- Proto Oncogene Proteins c bcr
- c-bcr, Proto-Oncogene Proteins
- Proto-Oncogene Protein c-bcr
- Proto Oncogene Protein c bcr
- c-bcr, Proto-Oncogene Protein
- Breakpoint Cluster Region Protein
- c-bcr Proteins
- c bcr Proteins
- c-bcr Proto-Oncogene Proteins
- Proto-Oncogene Proteins, c-bcr
- c bcr Proto Oncogene Proteins
- bcr Proto-Oncogene Proteins
- Proto-Oncogene Proteins, bcr
- bcr Proto Oncogene Proteins
- Proto-Oncogene Protein bcr
- Proto Oncogene Protein bcr
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-bcr".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-bcr".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-bcr" by people in this website by year, and whether "Proto-Oncogene Proteins c-bcr" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 3 | 3 |
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 6 | 6 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 2 | 1 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-bcr" by people in Profiles.
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Myeloid neoplasm with eosinophilia and BCR-JAK2/t(9;22)(p24;q11.2) morphologically mimicking chronic myeloid leukemia. Ann Diagn Pathol. 2020 Feb; 44:151405.
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The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest. Elife. 2019 08 28; 8.
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Myeloproliferative neoplasms with t(8;22)(p11.2;q11.2)/BCR-FGFR1: a meta-analysis of 20 cases shows cytogenetic progression with B-lymphoid blast phase. Hum Pathol. 2017 07; 65:147-156.
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The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2017 May 01; 23(9):2313-2324.
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PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle. PLoS One. 2015; 10(4):e0124494.
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The small GTPases RhoA and Rac1 regulate cerebellar development by controlling cell morphogenesis, migration and foliation. Dev Biol. 2014 Oct 01; 394(1):39-53.
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Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23; 29(6):701-15.
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The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity. Mol Biol Cell. 2013 Dec; 24(24):3857-68.
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A case of acute myelogenous leukaemia characterised by the BCR-FGFR1 translocation. BMJ Case Rep. 2013 Mar 20; 2013.
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10 years of progress in chronic myelogenous leukemia. J Natl Compr Canc Netw. 2012 Sep; 10(9):1049-53.