Rho Guanine Nucleotide Exchange Factors
"Rho Guanine Nucleotide Exchange Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Signaling proteins which function as master molecular switches by activating Rho GTPases through conversion of guanine nucleotides. Rho GTPases in turn control many aspects of cell behavior through the regulation of multiple downstream signal transduction pathways.
| Descriptor ID |
D064067
|
| MeSH Number(s) |
D12.644.360.325.300.099 D12.776.476.325.300.099
|
| Concept/Terms |
Rho Guanine Nucleotide Exchange Factor 7- Rho Guanine Nucleotide Exchange Factor 7
- PAK-Interacting Exchange Factor beta
- PAK Interacting Exchange Factor beta
- Cool-1 Protein
- Cool 1 Protein
- Protein, Cool-1
- beta PIX Protein
- PIX Protein, beta
- Protein, beta PIX
- betaPIX Protein
- Protein, betaPIX
|
Below are MeSH descriptors whose meaning is more general than "Rho Guanine Nucleotide Exchange Factors".
Below are MeSH descriptors whose meaning is more specific than "Rho Guanine Nucleotide Exchange Factors".
This graph shows the total number of publications written about "Rho Guanine Nucleotide Exchange Factors" by people in this website by year, and whether "Rho Guanine Nucleotide Exchange Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Rho Guanine Nucleotide Exchange Factors" by people in Profiles.
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Muscarinic receptor agonist-induced ?Pix binding to ?-catenin promotes colon neoplasia. Sci Rep. 2023 10 07; 13(1):16920.
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Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs. J Am Soc Nephrol. 2023 02 01; 34(2):273-290.
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Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement. Sci Adv. 2023 01 13; 9(2):eabq6480.
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Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, ?PIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice. Am J Physiol Gastrointest Liver Physiol. 2021 04 01; 320(4):G627-G643.
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Autism spectrum disorder in females with ARHGEF9 alterations and a random pattern of X chromosome inactivation. Eur J Med Genet. 2019 Apr; 62(4):239-242.
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Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. PLoS One. 2018; 13(7):e0197561.
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Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci. 2016 11 23; 36(47):11904-11917.
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Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state. J Biol Chem. 2015 Apr 17; 290(16):10353-67.
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The RhoGEF Net1 is required for normal mammary gland development. Mol Endocrinol. 2014 Dec; 28(12):1948-60.
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PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA. J Cell Sci. 2013 Oct 01; 126(Pt 19):4514-26.