"Casein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of protein-serine-threonine kinases that was originally identified as being responsible for the PHOSPHORYLATION of CASEINS. They are ubiquitous enzymes that have a preference for acidic proteins. Casein kinases play a role in SIGNAL TRANSDUCTION by phosphorylating a variety of regulatory cytoplasmic and regulatory nuclear proteins.
| Descriptor ID |
D047388
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.140 D12.776.476.150
|
| Concept/Terms |
Casein Kinases- Casein Kinases
- Kinases, Casein
- Casein Kinase
- Kinase, Casein
|
Below are MeSH descriptors whose meaning is more general than "Casein Kinases".
Below are MeSH descriptors whose meaning is more specific than "Casein Kinases".
This graph shows the total number of publications written about "Casein Kinases" by people in this website by year, and whether "Casein Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "Casein Kinases" by people in Profiles.
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Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival. Nature. 2009 Mar 05; 458(7234):92-6.
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Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene. 2004 May 27; 23(25):4422-9.
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Phosphorylation of the beta-galactoside-binding protein galectin-3 modulates binding to its ligands. J Biol Chem. 2000 Nov 17; 275(46):36311-5.
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The NH2 terminus of galectin-3 governs cellular compartmentalization and functions in cancer cells. Cancer Res. 1999 Dec 15; 59(24):6239-45.
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A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol. 1996 Nov; 16(11):6486-93.
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The consensus sequences for cdc2 kinase and for casein kinase-2 are mutually incompatible. A study with peptides derived from the beta-subunit of casein kinase-2. FEBS Lett. 1992 Apr 13; 301(1):111-4.