"Casein Kinase I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40 kDa. Several ISOENZYMES of casein kinase I have been found which are encoded by separate genes. Many of the casein kinase I isoenzymes have been shown to play distinctive roles in intracellular SIGNAL TRANSDUCTION.
| Descriptor ID |
D047389
|
| MeSH Number(s) |
D05.500.117.750 D08.811.913.696.620.682.700.140.300 D12.776.476.081.750 D12.776.476.150.299
|
| Concept/Terms |
Casein Kinase I- Casein Kinase I
- Kinase I, Casein
- Protein Kinase CKI
- Casein Kinase 1
- Kinase 1, Casein
- Protein Kinase CK1
|
Below are MeSH descriptors whose meaning is more general than "Casein Kinase I".
Below are MeSH descriptors whose meaning is more specific than "Casein Kinase I".
This graph shows the total number of publications written about "Casein Kinase I" by people in this website by year, and whether "Casein Kinase I" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Casein Kinase I" by people in Profiles.
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In vitro phosphorylation of von Willebrand factor by FAM20c enhances its ability to support platelet adhesion. J Thromb Haemost. 2019 06; 17(6):866-877.
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2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1?) inhibitors. Bioorg Med Chem Lett. 2012 Sep 01; 22(17):5392-5.
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MiR-155 is a liposarcoma oncogene that targets casein kinase-1a and enhances ?-catenin signaling. Cancer Res. 2012 Apr 01; 72(7):1751-62.
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Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis. PLoS One. 2012; 7(1):e30814.
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Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):101-6.
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Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members. J Cell Sci. 2010 Dec 15; 123(Pt 24):4351-65.
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Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila. Neuron. 2010 Sep 09; 67(5):810-20.
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Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 2010 Aug 09; 18(2):147-59.
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Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factors. PLoS One. 2008 Sep 05; 3(9):e3146.
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Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol. 2008 Jan; 10(1):70-6.