"Casein Kinase Ialpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the WNT SIGNALING PATHWAY, the CELL CYCLE, membrane trafficking, and RNA processing. Multiple isoforms of casein kinase I alpha exist and are due to ALTERNATIVE SPLICING.
| Descriptor ID |
D048128
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| MeSH Number(s) |
D05.500.117.750.100 D08.811.913.696.620.682.700.140.300.100 D12.776.476.081.750.100 D12.776.476.150.299.100
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Casein Kinase Ialpha".
Below are MeSH descriptors whose meaning is more specific than "Casein Kinase Ialpha".
This graph shows the total number of publications written about "Casein Kinase Ialpha" by people in this website by year, and whether "Casein Kinase Ialpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Casein Kinase Ialpha" by people in Profiles.
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Development of PDE6D and CK1a Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 01 13; 65(1):747-756.
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Casein kinase 1a decreases ?-catenin levels at adherens junctions to facilitate wound closure in Drosophila larvae. Development. 2019 10 02; 146(20).
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Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E12015-E12023.
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GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction. Cancer Res. 2011 Dec 15; 71(24):7694-704.
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Evidence of a role for activation of Wnt/beta-catenin signaling in the resistance of plasma cells to lenalidomide. J Biol Chem. 2011 Apr 01; 286(13):11009-20.
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Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction. Oncogene. 2010 Jun 10; 29(23):3324-34.