Platelet Glycoprotein GPIb-IX Complex
"Platelet Glycoprotein GPIb-IX Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
| Descriptor ID |
D019038
|
| MeSH Number(s) |
D12.776.395.550.625.460 D12.776.543.550.625.460 D12.776.543.750.705.675.568
|
| Concept/Terms |
CD42c Antigens- CD42c Antigens
- Glycoprotein Ib beta
- CD42c Antigen
- Antigen, CD42c
- Antigens, CD42c
CD42b Antigens- CD42b Antigens
- Antigens, CD42b
- Glycoprotein Ib alpha
- CD42b Antigen
- Antigen, CD42b
CD42d Antigen- CD42d Antigen
- Antigen, CD42d
- CD42d Antigens
- Antigens, CD42d
|
Below are MeSH descriptors whose meaning is more general than "Platelet Glycoprotein GPIb-IX Complex".
Below are MeSH descriptors whose meaning is more specific than "Platelet Glycoprotein GPIb-IX Complex".
This graph shows the total number of publications written about "Platelet Glycoprotein GPIb-IX Complex" by people in this website by year, and whether "Platelet Glycoprotein GPIb-IX Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 3 | 3 | 6 |
| 2004 | 1 | 2 | 3 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 2 | 0 | 2 |
| 2011 | 2 | 0 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 2 | 3 |
| 2014 | 0 | 1 | 1 |
| 2015 | 4 | 0 | 4 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Platelet Glycoprotein GPIb-IX Complex" by people in Profiles.
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High levels of von Willebrand factor with reduced specific activities in hospitalized patients with or without COVID-19. J Thromb Thrombolysis. 2022 Aug; 54(2):211-216.
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Glycoprotein V : the unsolved GPV puzzle. Platelets. 2022 Aug 18; 33(6):833-840.
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Association of Oxidative Stress and Platelet Receptor Glycoprotein GPIba and GPVI Shedding During Nonsurgical Bleeding in Heart Failure Patients With Continuous-Flow Left Ventricular Assist Device Support. ASAIO J. 2018 Jul/Aug; 64(4):462-471.
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MicroRNAs 10a and 10b Regulate the Expression of Human Platelet Glycoprotein Iba for Normal Megakaryopoiesis. Int J Mol Sci. 2016 Nov 09; 17(11).
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Membrane skeleton orchestrates the platelet glycoprotein (GP) Ib-IX complex clustering and signaling. IUBMB Life. 2016 10; 68(10):823-9.
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Defective Association of the Platelet Glycoprotein Ib-IX Complex with the Glycosphingolipid-Enriched Membrane Domain Inhibits Murine Thrombus and Atheroma Formation. J Immunol. 2016 07 01; 197(1):288-95.
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Inhibition of Hb Binding to GP1ba Abrogates Hb-Mediated Thrombus Formation on Immobilized VWF and Collagen under Physiological Shear Stress. PLoS One. 2016; 11(4):e0154276.
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Allorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoeba Dictyostelium discoideum. Development. 2015 Oct 15; 142(20):3561-70.
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Hemoglobin interaction with GP1ba induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. Haematologica. 2015 Dec; 100(12):1526-33.
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Von Willebrand factor-A1 domain binds platelet glycoprotein Iba in multiple states with distinctive force-dependent dissociation kinetics. Thromb Res. 2015 Sep; 136(3):606-12.