"Integrin alpha2beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
| Descriptor ID |
D038982
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| MeSH Number(s) |
D12.776.395.550.625.298 D12.776.543.550.625.298 D12.776.543.750.685.200 D12.776.543.750.705.408.530.249 D12.776.543.750.705.408.850.199 D12.776.543.750.705.675.352 D12.776.543.750.705.876.280
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| Concept/Terms |
Integrin alpha2beta1- Integrin alpha2beta1
- alpha2beta1, Integrin
- VLA-2
- VLA 2
- Glycoprotein Ia-IIa
- Glycoprotein Ia IIa
- alpha2beta1Integrin
- Very Late Antigen-2
- Late Antigen-2, Very
- Very Late Antigen 2
- CD49b-CD29
- CD49b CD29
- Platelet Membrane Glycoprotein Heterodimer Ia-IIa
- Platelet Membrane Glycoprotein Heterodimer Ia IIa
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha2beta1".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha2beta1".
This graph shows the total number of publications written about "Integrin alpha2beta1" by people in this website by year, and whether "Integrin alpha2beta1" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alpha2beta1" by people in Profiles.
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CC16 drives VLA-2-dependent SPLUNC1 expression. Front Immunol. 2023; 14:1277582.
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Integrin a2?1 mediates tyrosine phosphorylation of vascular endothelial cadherin induced by invasive breast cancer cells. J Biol Chem. 2012 Sep 21; 287(39):32981-92.
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Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8811-8.
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Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med. 2007 Dec 24; 204(13):3103-11.
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Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. J Biol Chem. 2006 Oct 13; 281(41):30383-92.
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C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen. Blood. 2006 Jan 15; 107(2):423-30.
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The platelet glycoprotein Ib-von Willebrand factor interaction activates the collagen receptor alpha2beta1 to bind collagen: activation-dependent conformational change of the alpha2-I domain. Blood. 2005 Mar 01; 105(5):1986-91.
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Clinical and functional consequences of platelet membrane glycoprotein polymorphisms. Semin Thromb Hemost. 2004 Oct; 30(5):591-600.
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Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironment. Cancer Res. 2003 Dec 01; 63(23):8312-7.
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The alpha(2)beta(1) and alpha(3)beta(1) integrins do not mediate attachment of endometrial cells to peritoneal mesothelium. Fertil Steril. 2002 Oct; 78(4):796-803.