"Integrin alpha3beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell surface receptor for LAMININ, epiligrin, FIBRONECTINS, entactin, and COLLAGEN. Integrin alpha3beta1 is the major integrin present in EPITHELIAL CELLS, where it plays a role in the assembly of BASEMENT MEMBRANE as well as in cell migration, and may regulate the functions of other integrins. Two alternatively spliced isoforms of the alpha subunit (INTEGRIN ALPHA3), are differentially expressed in different cell types.
| Descriptor ID |
D039201
|
| MeSH Number(s) |
D12.776.543.750.685.300 D12.776.543.750.705.408.850.249 D12.776.543.750.705.876.311
|
| Concept/Terms |
Integrin alpha3beta1- Integrin alpha3beta1
- alpha3beta1, Integrin
- Gap b3
- VLA-3
- alpha3beta1 Epiligrin Receptor
- Epiligrin Receptor, alpha3beta1
- Receptor, alpha3beta1 Epiligrin
- Epiligrin Receptor
- Receptor, Epiligrin
- Galactoprotein b3
- Integrin alpha(3)beta(1)
- Laminin-5 Receptor (alpha3beta1 integrin)
- CD49c-CD29
- alpha3beta1 Integrin
- Integrin, alpha3beta1
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha3beta1".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha3beta1".
This graph shows the total number of publications written about "Integrin alpha3beta1" by people in this website by year, and whether "Integrin alpha3beta1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrin alpha3beta1" by people in Profiles.
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Oncogenic collagen I homotrimers from cancer cells bind to a3?1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer. Cancer Cell. 2022 08 08; 40(8):818-834.e9.
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Integrin a3?1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt. Mol Biol Cell. 2015 May 15; 26(10):1857-74.
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Alpha3beta1-integrin as a critical mediator of the hepatic differentiation response to the extracellular matrix. Hepatology. 1998 Oct; 28(4):1095-104.
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A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J Biol Chem. 1997 Jan 31; 272(5):2595-8.
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Modulation of matrix metalloprotease-2 and invasion in human glioma cells by alpha 3 beta 1 integrin. Cancer Lett. 1996 Jun 05; 103(2):201-8.