"Integrin alpha6beta4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
| Descriptor ID |
D039161
|
| MeSH Number(s) |
D12.776.543.750.705.408.460.170 D12.776.543.750.705.876.750
|
| Concept/Terms |
Integrin alpha6beta4- Integrin alpha6beta4
- alpha6beta4, Integrin
- alpha(6)beta(4) Integrin
- alpha6 beta4 Integrin
- Integrin, alpha6 beta4
- beta4 Integrin, alpha6
- Integrin alpha(6),beta(4)
- A9 Antigen
- Antigen, A9
- TSP-180
- Tumor Specific Protein-180 Complex
- Tumor Specific Protein 180 Complex
- alpha(6)beta(4) Epithelial Integrin
- Laminin-5 Receptor (alpha6beta4 Integrin)
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha6beta4".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha6beta4".
This graph shows the total number of publications written about "Integrin alpha6beta4" by people in this website by year, and whether "Integrin alpha6beta4" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 3 | 3 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 2 | 2 |
| 2003 | 1 | 0 | 1 |
| 2004 | 3 | 0 | 3 |
| 2005 | 2 | 0 | 2 |
| 2007 | 1 | 0 | 1 |
| 2009 | 3 | 0 | 3 |
| 2011 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Integrin alpha6beta4" by people in Profiles.
-
Loss of keratins 8 and 18 leads to alterations in a6?4-integrin-mediated signalling and decreased neoplastic progression in an oral-tumour-derived cell line. J Cell Sci. 2011 Jun 15; 124(Pt 12):2096-106.
-
Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling. Mol Cancer Res. 2009 Jul; 7(7):1119-31.
-
Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer. J Exp Clin Cancer Res. 2009 May 26; 28:67.
-
Coexpression of alpha6beta4 integrin and guanine nucleotide exchange factor Net1 identifies node-positive breast cancer patients at high risk for distant metastasis. Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18(1):80-6.
-
PTHrP contributes to the anti-proliferative and integrin alpha6beta4-regulating effects of 1,25-dihydroxyvitamin D(3). Steroids. 2007 Dec; 72(14):930-8.
-
Beta4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancer. Mod Pathol. 2005 Sep; 18(9):1165-75.
-
Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol Cell Biol. 2005 Jul; 25(14):6090-102.
-
Integrin beta4 signaling promotes tumor angiogenesis. Cancer Cell. 2004 Nov; 6(5):471-83.
-
Adhesion-independent alpha6beta4 integrin clustering is mediated by phosphatidylinositol 3-kinase. Cancer Res. 2004 Oct 15; 64(20):7395-8.
-
Chromogenic in situ hybridization for alpha6beta4 integrin in breast cancer: correlation with protein expression. J Mol Diagn. 2004 Feb; 6(1):10-5.