Platelet Glycoprotein GPIIb-IIIa Complex
"Platelet Glycoprotein GPIIb-IIIa Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
| Descriptor ID |
D019039
|
| MeSH Number(s) |
D12.776.395.550.625.785 D12.776.543.550.625.785 D12.776.543.750.705.408.460.700 D12.776.543.750.705.675.784
|
| Concept/Terms |
Platelet Glycoprotein GPIIb-IIIa Complex- Platelet Glycoprotein GPIIb-IIIa Complex
- Platelet Glycoprotein GPIIb IIIa Complex
- Glycoproteins IIb-IIIa
- Glycoproteins IIb IIIa
- Integrin alpha-IIb beta-3
- Integrin alpha IIb beta 3
- beta-3, Integrin alpha-IIb
- Integrin alphaIIbbeta3
- alphaIIbbeta3, Integrin
- GPIIb-IIIa Receptors
- GPIIb IIIa Receptors
- Receptors, GPIIb-IIIa
|
Below are MeSH descriptors whose meaning is more general than "Platelet Glycoprotein GPIIb-IIIa Complex".
Below are MeSH descriptors whose meaning is more specific than "Platelet Glycoprotein GPIIb-IIIa Complex".
This graph shows the total number of publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in this website by year, and whether "Platelet Glycoprotein GPIIb-IIIa Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 3 | 1 | 4 |
| 2000 | 1 | 0 | 1 |
| 2001 | 2 | 2 | 4 |
| 2002 | 3 | 2 | 5 |
| 2003 | 3 | 3 | 6 |
| 2004 | 1 | 3 | 4 |
| 2005 | 0 | 1 | 1 |
| 2006 | 2 | 1 | 3 |
| 2007 | 0 | 2 | 2 |
| 2008 | 4 | 0 | 4 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 0 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 3 | 4 |
| 2017 | 0 | 1 | 1 |
| 2023 | 2 | 0 | 2 |
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Below are the most recent publications written about "Platelet Glycoprotein GPIIb-IIIa Complex" by people in Profiles.
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Opposing Roles for the a Isoform of the Catalytic Subunit of Protein Phosphatase 1 in Inside-Out and Outside-In Integrin Signaling in Murine Platelets. Cells. 2023 10 10; 12(20).
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Molecular dynamics simulations corroborate recombinant expression studies carried out on three aIIb ?-propeller mutations reported in Indian Glanzmann thrombasthenia patients. J Cell Biochem. 2023 07; 124(7):989-1001.
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High shear induces platelet dysfunction leading to enhanced thrombotic propensity and diminished hemostatic capacity. Platelets. 2019; 30(1):112-119.
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Impact of Glycoprotein IIb/IIIa Inhibitors Use on Outcomes After Lower Extremity Endovascular Interventions From Nationwide Inpatient Sample (2006-2011). Catheter Cardiovasc Interv. 2016 10; 88(4):616-617.
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Wdr1-Dependent Actin Reorganization in Platelet Activation. PLoS One. 2016; 11(9):e0162897.
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The Last Detail: Platelets, Glycoprotein IIb/IIIa Antagonists, and Excipients. JACC Cardiovasc Interv. 2016 08 22; 9(16):1677-9.
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A whole blood model of thrombocytopenia that controls platelet count and hematocrit. Ann Hematol. 2016 Oct; 95(11):1887-94.
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A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in aIIb?3 Integrin Signaling. J Biol Chem. 2016 08 12; 291(33):17360-8.
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Activation and shedding of platelet glycoprotein IIb/IIIa under non-physiological shear stress. Mol Cell Biochem. 2015 Nov; 409(1-2):93-101.
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The ? isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in aII b ?3 integrin signaling. J Thromb Haemost. 2014 Dec; 12(12):2089-101.