"Integrin alphaVbeta3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
| Descriptor ID |
D039302
|
| MeSH Number(s) |
D12.776.395.550.625.439 D12.776.543.550.625.439 D12.776.543.750.705.408.460.870.500 D12.776.543.750.705.675.541
|
| Concept/Terms |
Integrin alphaVbeta3- Integrin alphaVbeta3
- alphaVbeta3, Integrin
- alpha-v beta-3 Integrin Receptors
- alpha v beta 3 Integrin Receptors
- Receptors, alpha-v beta-3 Integrin
- Receptors, alpha v beta 3 Integrin
- Vitronectin Receptor
- Receptor, Vitronectin
- Integrin alpha-v beta-3
- Integrin alpha v beta 3
- alpha-v beta-3, Integrin
- beta-3, Integrin alpha-v
|
Below are MeSH descriptors whose meaning is more general than "Integrin alphaVbeta3".
Below are MeSH descriptors whose meaning is more specific than "Integrin alphaVbeta3".
This graph shows the total number of publications written about "Integrin alphaVbeta3" by people in this website by year, and whether "Integrin alphaVbeta3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 4 | 4 |
| 2003 | 3 | 0 | 3 |
| 2004 | 2 | 0 | 2 |
| 2005 | 4 | 0 | 4 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 2 | 3 |
| 2008 | 2 | 1 | 3 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2014 | 2 | 1 | 3 |
| 2015 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alphaVbeta3" by people in Profiles.
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Effect of Dose and Selection of Two Different Ligands on the Deposition and Antitumor Efficacy of Targeted Nanoparticles in Brain Tumors. Mol Pharm. 2019 10 07; 16(10):4352-4360.
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Integrin av?3-Targeted [64Cu]CuS Nanoparticles for PET/CT Imaging and Photothermal Ablation Therapy. Bioconjug Chem. 2018 12 19; 29(12):4062-4071.
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Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors. Biochim Biophys Acta Mol Basis Dis. 2017 09; 1863(9):2342-2354.
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Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle. Cancer Res. 2015 Apr 01; 75(7):1356-65.
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alphaVbeta3-targeted copper nanoparticles incorporating an Sn 2 lipase-labile fumagillin prodrug for photoacoustic neovascular imaging and treatment. Theranostics. 2015; 5(2):124-33.
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(99m)Tc-labeled aminosilane-coated iron oxide nanoparticles for molecular imaging of a??3-mediated tumor expression and feasibility for hyperthermia treatment. J Colloid Interface Sci. 2014 Nov 01; 433:163-175.
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An integrin ?3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol. 2014 May; 16(5):457-68.
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Integrins av?5 and av?3 promote latent TGF-?1 activation by human cardiac fibroblast contraction. Cardiovasc Res. 2014 Jun 01; 102(3):407-17.
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Serial non-invasive monitoring of renal disease following immune-mediated injury using near-infrared optical imaging. PLoS One. 2012; 7(9):e43941.
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Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy. J Neural Transm (Vienna). 2012 Jan; 119(1):59-71.