"Integrins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
| Descriptor ID |
D016023
|
| MeSH Number(s) |
D12.776.543.750.705.408
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Integrins".
Below are MeSH descriptors whose meaning is more specific than "Integrins".
This graph shows the total number of publications written about "Integrins" by people in this website by year, and whether "Integrins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 3 | 3 | 6 |
| 1996 | 7 | 1 | 8 |
| 1997 | 4 | 3 | 7 |
| 1998 | 6 | 3 | 9 |
| 1999 | 9 | 1 | 10 |
| 2000 | 8 | 4 | 12 |
| 2001 | 4 | 8 | 12 |
| 2002 | 8 | 9 | 17 |
| 2003 | 4 | 5 | 9 |
| 2004 | 4 | 7 | 11 |
| 2005 | 5 | 3 | 8 |
| 2006 | 1 | 5 | 6 |
| 2007 | 7 | 3 | 10 |
| 2008 | 2 | 5 | 7 |
| 2009 | 6 | 4 | 10 |
| 2010 | 5 | 1 | 6 |
| 2011 | 3 | 3 | 6 |
| 2012 | 1 | 1 | 2 |
| 2013 | 2 | 4 | 6 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 2 | 4 |
| 2017 | 4 | 1 | 5 |
| 2018 | 2 | 1 | 3 |
| 2019 | 4 | 0 | 4 |
| 2020 | 3 | 1 | 4 |
| 2021 | 2 | 0 | 2 |
| 2022 | 0 | 4 | 4 |
| 2023 | 1 | 4 | 5 |
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Below are the most recent publications written about "Integrins" by people in Profiles.
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Structural surfaceomics reveals an AML-specific conformation of integrin ?2 as a CAR T cellular therapy target. Nat Cancer. 2023 Nov; 4(11):1592-1609.
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Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia. Nat Commun. 2023 10 07; 14(1):6270.
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An altered extracellular matrix-integrin interface contributes to Huntington's disease-associated CNS dysfunction in glial and vascular cells. Hum Mol Genet. 2023 04 20; 32(9):1483-1496.
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The alpha7 integrin subunit in astrocytes promotes endothelial blood-brain barrier integrity. Development. 2023 03 15; 150(6).
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Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs. J Am Soc Nephrol. 2023 02 01; 34(2):273-290.
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Identification of amino acid domains of Borrelia burgdorferi P66 that are surface exposed and important for localization, oligomerization, and porin function of the protein. Front Cell Infect Microbiol. 2022; 12:991689.
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Noncanonical Wnt/Ror2 signaling regulates cell-matrix adhesion to prompt directional tumor cell invasion in breast cancer. Mol Biol Cell. 2022 09 15; 33(11):ar103.
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Integrins in cardiac fibrosis. J Mol Cell Cardiol. 2022 11; 172:1-13.
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The focal adhesion protein ?-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load. Curr Biol. 2022 07 25; 32(14):3033-3047.e9.
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The ?8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development. Development. 2022 03 15; 149(6).