Signaling Lymphocytic Activation Molecule Family
"Signaling Lymphocytic Activation Molecule Family" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.
| Descriptor ID |
D000071176
|
| MeSH Number(s) |
D12.776.395.550.736 D12.776.543.550.746 D12.776.543.750.705.970
|
| Concept/Terms |
Signaling Lymphocytic Activation Molecule Family- Signaling Lymphocytic Activation Molecule Family
- Signaling Lymphocytic Activation Molecule Receptors
- SLAMF Receptors
- Signaling Lymphocytic Activation Molecule Family Receptors
- Signaling Lymphocytic Activation Molecules
- SLAM Family Receptors
|
Below are MeSH descriptors whose meaning is more general than "Signaling Lymphocytic Activation Molecule Family".
Below are MeSH descriptors whose meaning is more specific than "Signaling Lymphocytic Activation Molecule Family".
This graph shows the total number of publications written about "Signaling Lymphocytic Activation Molecule Family" by people in this website by year, and whether "Signaling Lymphocytic Activation Molecule Family" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Signaling Lymphocytic Activation Molecule Family" by people in Profiles.
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SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment. J Immunol. 2021 01 01; 206(1):193-205.
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SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer. Cancer Immunol Res. 2019 09; 7(9):1485-1496.
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SLAMF7 Is a Critical Negative Regulator of IFN-a-Mediated CXCL10 Production in Chronic HIV Infection. J Immunol. 2019 01 01; 202(1):228-238.
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2B4 (CD244, SLAMF4) and CS1 (CD319, SLAMF7) in systemic lupus erythematosus and cancer. Clin Immunol. 2019 07; 204:50-56.
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Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma. N Engl J Med. 2015 Aug 13; 373(7):621-31.
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NKG2D ligation relieves 2B4-mediated NK-cell self-tolerance in mice. Eur J Immunol. 2014 Jun; 44(6):1802-13.
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Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. Immunity. 2009 Jul 17; 31(1):99-109.