Signaling Lymphocytic Activation Molecule Family Member 1
"Signaling Lymphocytic Activation Molecule Family Member 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 70-kDa SLAM family receptor that consists of an extracellular IMMUNOGLOBULIN-LIKE DOMAIN and an IMMUNOGLOBULIN C2-SET DOMAIN. It is expressed primarily by THYMOCYTES and activated T-LYMPHOCYTES, as well as by MACROPHAGES and DENDRITIC CELLS. It binds SLAMF1 receptors on other cells to mediate T-cell maturation and proliferation. It is also a receptor for the MEASLES VIRUS.
| Descriptor ID |
D000071177
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| MeSH Number(s) |
D12.776.395.550.736.500 D12.776.543.550.746.500 D12.776.543.750.705.970.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Signaling Lymphocytic Activation Molecule Family Member 1".
Below are MeSH descriptors whose meaning is more specific than "Signaling Lymphocytic Activation Molecule Family Member 1".
This graph shows the total number of publications written about "Signaling Lymphocytic Activation Molecule Family Member 1" by people in this website by year, and whether "Signaling Lymphocytic Activation Molecule Family Member 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Signaling Lymphocytic Activation Molecule Family Member 1" by people in Profiles.
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Interaction of Signaling Lymphocytic Activation Molecule Family 1 (SLAMF1) receptor with Trypanosoma cruzi is strain-dependent and affects NADPH oxidase expression and activity. PLoS Negl Trop Dis. 2020 09; 14(9):e0008608.
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A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia. PLoS One. 2011; 6(12):e28277.
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Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed. J Clin Invest. 2008 Jul; 118(7):2448-58.
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Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150). J Biol Chem. 2008 Apr 25; 283(17):11763-71.
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CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells. Blood. 2008 Feb 15; 111(4):2444-51.
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Nearby clusters of hemagglutinin residues sustain SLAM-dependent canine distemper virus entry in peripheral blood mononuclear cells. J Virol. 2005 May; 79(9):5857-62.
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Selectively receptor-blind measles viruses: Identification of residues necessary for SLAM- or CD46-induced fusion and their localization on a new hemagglutinin structural model. J Virol. 2004 Jan; 78(1):302-13.