"4-1BB Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane bound member of the TNF superfamily that is expressed on activated B-LYMPHOCYTES; MACROPHAGES; and DENDRITIC CELLS. The ligand is specific for the 4-1BB RECEPTOR and may play a role in inducing the proliferation of activated peripheral blood T-LYMPHOCYTES.
| Descriptor ID |
D053330
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| MeSH Number(s) |
D12.644.276.374.750.065 D12.776.395.192 D12.776.467.374.750.065 D12.776.543.550.194 D23.529.374.750.065
|
| Concept/Terms |
4-1BB Ligand- 4-1BB Ligand
- 4 1BB Ligand
- Tumor Necrosis Factor Ligand Superfamily Member 9
- Tumor Necrosis Factor (Ligand) Superfamily, Member 9
- 4-1BBL Protein
- 4 1BBL Protein
- CD137 Ligand
|
Below are MeSH descriptors whose meaning is more general than "4-1BB Ligand".
Below are MeSH descriptors whose meaning is more specific than "4-1BB Ligand".
This graph shows the total number of publications written about "4-1BB Ligand" by people in this website by year, and whether "4-1BB Ligand" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "4-1BB Ligand" by people in Profiles.
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Designed improvement to T-cell immunotherapy by multidimensional single cell profiling. J Immunother Cancer. 2021 03; 9(3).
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Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent. Cell Rep. 2017 Oct 03; 21(1):17-26.
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Immune checkpoint combinations from mouse to man. Cancer Immunol Immunother. 2015 Jul; 64(7):885-92.
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Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy. Blood. 2014 Oct 30; 124(18):2824-33.
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HIV-1 adenoviral vector vaccines expressing multi-trimeric BAFF and 4-1BBL enhance T cell mediated anti-viral immunity. PLoS One. 2014; 9(2):e90100.
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Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications. Cytotherapy. 2012 Oct; 14(9):1131-43.
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Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur J Immunol. 1993 Oct; 23(10):2631-41.