"Asialoglycoproteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.
| Descriptor ID |
D001212
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| MeSH Number(s) |
D12.776.395.140
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Asialoglycoproteins".
Below are MeSH descriptors whose meaning is more specific than "Asialoglycoproteins".
This graph shows the total number of publications written about "Asialoglycoproteins" by people in this website by year, and whether "Asialoglycoproteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Asialoglycoproteins" by people in Profiles.
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Region-specific ontogeny of alpha-2,6-sialyltransferase during normal and cortisone-induced maturation in mouse intestine. Am J Physiol Gastrointest Liver Physiol. 2002 Mar; 282(3):G480-90.
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Phosphorylation of the beta-galactoside-binding protein galectin-3 modulates binding to its ligands. J Biol Chem. 2000 Nov 17; 275(46):36311-5.
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Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11548-52.
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Modulation of the liver specific phenotype in the human hepatoblastoma line Hep G2. In Vitro Cell Dev Biol. 1989 Feb; 25(2):217-22.