Tumor Necrosis Factor-alpha
"Tumor Necrosis Factor-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
| Descriptor ID |
D014409
|
| MeSH Number(s) |
D12.644.276.374.500.800 D12.644.276.374.750.626 D12.776.124.900 D12.776.395.930 D12.776.467.374.500.800 D12.776.467.374.750.626 D23.529.374.500.800 D23.529.374.750.626
|
| Concept/Terms |
Tumor Necrosis Factor-alpha- Tumor Necrosis Factor-alpha
- Tumor Necrosis Factor alpha
- Cachectin
- Cachectin-Tumor Necrosis Factor
- Cachectin Tumor Necrosis Factor
- Tumor Necrosis Factor Ligand Superfamily Member 2
- Tumor Necrosis Factor
- TNF Superfamily, Member 2
- TNFalpha
- TNF-alpha
|
Below are MeSH descriptors whose meaning is more general than "Tumor Necrosis Factor-alpha".
Below are MeSH descriptors whose meaning is more specific than "Tumor Necrosis Factor-alpha".
This graph shows the total number of publications written about "Tumor Necrosis Factor-alpha" by people in this website by year, and whether "Tumor Necrosis Factor-alpha" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 1 | 4 |
| 1997 | 4 | 5 | 9 |
| 1998 | 2 | 5 | 7 |
| 1999 | 5 | 10 | 15 |
| 2000 | 7 | 10 | 17 |
| 2001 | 8 | 14 | 22 |
| 2002 | 5 | 17 | 22 |
| 2003 | 8 | 17 | 25 |
| 2004 | 5 | 19 | 24 |
| 2005 | 9 | 15 | 24 |
| 2006 | 4 | 13 | 17 |
| 2007 | 5 | 14 | 19 |
| 2008 | 12 | 11 | 23 |
| 2009 | 6 | 14 | 20 |
| 2010 | 6 | 15 | 21 |
| 2011 | 7 | 11 | 18 |
| 2012 | 3 | 16 | 19 |
| 2013 | 5 | 14 | 19 |
| 2014 | 6 | 6 | 12 |
| 2015 | 6 | 14 | 20 |
| 2016 | 2 | 9 | 11 |
| 2017 | 2 | 9 | 11 |
| 2018 | 2 | 9 | 11 |
| 2019 | 2 | 13 | 15 |
| 2020 | 2 | 9 | 11 |
| 2021 | 0 | 8 | 8 |
| 2022 | 1 | 9 | 10 |
| 2023 | 1 | 4 | 5 |
| 2024 | 0 | 3 | 3 |
| 2025 | 1 | 2 | 3 |
| 2026 | 1 | 5 | 6 |
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Below are the most recent publications written about "Tumor Necrosis Factor-alpha" by people in Profiles.
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Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-a triggers tumorigenic inflammation in neuroblastoma. J Immunother Cancer. 2023 03; 11(3).
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SMAC Mimetic/IAP Inhibitor Birinapant Enhances Radiosensitivity of Glioblastoma Multiforme. Radiat Res. 2021 06 01; 195(6):549-560.
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NF-?B Blockade by NEMO Binding Domain Peptide Ameliorates Inflammation and Neurobehavioral Sequelae After Cranial Radiation Therapy in Juvenile Mice. Int J Radiat Oncol Biol Phys. 2021 04 01; 109(5):1508-1520.
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Modulating TNFa activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia. J Immunother Cancer. 2020 09; 8(2).
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Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFa-dependent but microbiota-independent tertiary lymphoid tissue formation. Mucosal Immunol. 2020 11; 13(6):908-918.
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Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy. Nat Commun. 2020 01 31; 11(1):661.
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Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies. Cancer Lett. 2019 12 28; 467:1-8.
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Immunological Responses to the Relapsing Fever Spirochete Borrelia turicatae in Infected Rhesus Macaques: Implications for Pathogenesis and Diagnosis. Infect Immun. 2019 04; 87(4).
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Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits. Nat Commun. 2019 01 04; 10(1):58.
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Anti TNF-a therapy in patients with relapsed and refractory Langerhans cell histiocytosis: a phase II study. Pediatr Hematol Oncol. 2018 Aug - Sep; 35(5-6):362-368.