Tumor Necrosis Factor-alpha
"Tumor Necrosis Factor-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
| Descriptor ID |
D014409
|
| MeSH Number(s) |
D12.644.276.374.500.800 D12.644.276.374.750.626 D12.776.124.900 D12.776.395.930 D12.776.467.374.500.800 D12.776.467.374.750.626 D23.529.374.500.800 D23.529.374.750.626
|
| Concept/Terms |
Tumor Necrosis Factor-alpha- Tumor Necrosis Factor-alpha
- Tumor Necrosis Factor alpha
- Cachectin
- Cachectin-Tumor Necrosis Factor
- Cachectin Tumor Necrosis Factor
- Tumor Necrosis Factor Ligand Superfamily Member 2
- Tumor Necrosis Factor
- TNF Superfamily, Member 2
- TNFalpha
- TNF-alpha
|
Below are MeSH descriptors whose meaning is more general than "Tumor Necrosis Factor-alpha".
Below are MeSH descriptors whose meaning is more specific than "Tumor Necrosis Factor-alpha".
This graph shows the total number of publications written about "Tumor Necrosis Factor-alpha" by people in this website by year, and whether "Tumor Necrosis Factor-alpha" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 1 | 4 |
| 1997 | 4 | 5 | 9 |
| 1998 | 2 | 5 | 7 |
| 1999 | 5 | 10 | 15 |
| 2000 | 7 | 10 | 17 |
| 2001 | 8 | 14 | 22 |
| 2002 | 5 | 17 | 22 |
| 2003 | 8 | 17 | 25 |
| 2004 | 5 | 19 | 24 |
| 2005 | 9 | 15 | 24 |
| 2006 | 4 | 13 | 17 |
| 2007 | 5 | 14 | 19 |
| 2008 | 12 | 11 | 23 |
| 2009 | 6 | 14 | 20 |
| 2010 | 6 | 15 | 21 |
| 2011 | 7 | 11 | 18 |
| 2012 | 3 | 16 | 19 |
| 2013 | 5 | 14 | 19 |
| 2014 | 6 | 6 | 12 |
| 2015 | 6 | 14 | 20 |
| 2016 | 2 | 9 | 11 |
| 2017 | 2 | 9 | 11 |
| 2018 | 2 | 9 | 11 |
| 2019 | 2 | 13 | 15 |
| 2020 | 2 | 9 | 11 |
| 2021 | 0 | 8 | 8 |
| 2022 | 1 | 9 | 10 |
| 2023 | 1 | 4 | 5 |
| 2024 | 0 | 3 | 3 |
| 2025 | 1 | 2 | 3 |
| 2026 | 1 | 5 | 6 |
To return to the timeline,
click here.
Below are the most recent publications written about "Tumor Necrosis Factor-alpha" by people in Profiles.
-
Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis. Cell Rep. 2026 Jun 23; 45(6):117417.
-
Hyperglycemia: A determinant of cardiac autonomic dysfunction in youth with obesity across the spectrum of glycemic regulation. Pediatr Obes. 2023 10; 18(10):e13063.
-
Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-a triggers tumorigenic inflammation in neuroblastoma. J Immunother Cancer. 2023 03; 11(3).
-
Podocyte derived TNF-a mediates monocyte differentiation and contributes to glomerular injury. FASEB J. 2022 12; 36(12):e22622.
-
Acute and Chronic Effects of Adjuvant Therapy on Inflammatory Markers in Breast Cancer Patients. JNCI Cancer Spectr. 2022 07 01; 6(4).
-
Rubella Virus Infected Macrophages and Neutrophils Define Patterns of Granulomatous Inflammation in Inborn and Acquired Errors of Immunity. Front Immunol. 2021; 12:796065.
-
Circulatory Endothelin 1-Regulating RNAs Panel: Promising Biomarkers for Non-Invasive NAFLD/NASH Diagnosis and Stratification: Clinical and Molecular Pilot Study. Genes (Basel). 2021 11 18; 12(11).
-
SMAC Mimetic/IAP Inhibitor Birinapant Enhances Radiosensitivity of Glioblastoma Multiforme. Radiat Res. 2021 06 01; 195(6):549-560.
-
Anti-inflammatory Effects of S. cumini Seed Extract on Gelatinase-B (MMP-9) Regulation against Hyperglycemic Cardiomyocyte Stress. Oxid Med Cell Longev. 2021; 2021:8839479.
-
NF-?B Blockade by NEMO Binding Domain Peptide Ameliorates Inflammation and Neurobehavioral Sequelae After Cranial Radiation Therapy in Juvenile Mice. Int J Radiat Oncol Biol Phys. 2021 04 01; 109(5):1508-1520.