"alpha 1-Antichymotrypsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.
| Descriptor ID |
D000514
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| MeSH Number(s) |
D12.644.861.030 D12.776.124.050.050 D12.776.124.790.106.050 D12.776.377.715.085.050 D12.776.395.045 D12.776.872.030
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "alpha 1-Antichymotrypsin".
Below are MeSH descriptors whose meaning is more specific than "alpha 1-Antichymotrypsin".
This graph shows the total number of publications written about "alpha 1-Antichymotrypsin" by people in this website by year, and whether "alpha 1-Antichymotrypsin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "alpha 1-Antichymotrypsin" by people in Profiles.
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Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates. J Med Chem. 2007 Nov 01; 50(22):5357-63.
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Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins. Clin Cancer Res. 2005 Feb 01; 11(3):1110-8.
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TIMP1 and SERPIN-A overexpression and TFF3 and CRABP1 underexpression as biomarkers for papillary thyroid carcinoma. Head Neck. 2004 Dec; 26(12):1069-83.
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Role of alpha-1-antichymotrypsin deficiency in promoting cirrhosis in two siblings with heterozygous alpha-1-antitrypsin deficiency phenotype SZ. Gut. 2002 May; 50(5):730-2.
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Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. Nat Neurosci. 2000 Feb; 3(2):157-63.
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Molecular evolution of serpins: homologous structure of the human alpha 1-antichymotrypsin and alpha 1-antitrypsin genes. Biochemistry. 1987 Dec 01; 26(24):7755-9.
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A comparative marker study of large cell lymphoma, Hodgkin's disease, and true histiocytic lymphoma in paraffin-embedded tissue. Am J Clin Pathol. 1986 Nov; 86(5):591-9.