"Syndecans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transmembrane glycoproteins that contain a short cytoplasmic domain, a single-span transmembrane domain, and an extracellular domain with heparin sulfate and CHONDROITIN SULFATE chains. Syndecans interact with a variety of heparin-binding INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS and may play a role in modulating cellular signaling during EMBRYONIC DEVELOPMENT, tumorigenesis, and angiogenesis.
| Descriptor ID |
D053667
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| MeSH Number(s) |
D12.776.395.550.847 D12.776.395.650.350.500 D12.776.543.550.847
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Syndecans".
Below are MeSH descriptors whose meaning is more specific than "Syndecans".
This graph shows the total number of publications written about "Syndecans" by people in this website by year, and whether "Syndecans" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "Syndecans" by people in Profiles.
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Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20782-7.
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Primary plasma cell leukemia: morphologic, immunophenotypic, and cytogenetic features of 4 cases treated with chemotherapy and stem cell transplantation. Ann Diagn Pathol. 2006 Oct; 10(5):263-8.
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Endogenous attenuation of allergic lung inflammation by syndecan-1. J Immunol. 2005 May 01; 174(9):5758-65.
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Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod. 2005 May; 72(5):1241-55.
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Syndecan-1 expression in locally invasive and metastatic prostate cancer. Urology. 2004 Feb; 63(2):402-7.
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Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood. 2004 Apr 15; 103(8):3175-84.
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Neoglycans, carbodiimide-modified glycosaminoglycans: a new class of anticancer agents that inhibit cancer cell proliferation and induce apoptosis. Cancer Res. 2002 Jul 01; 62(13):3722-8.