"Thrombospondins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
| Descriptor ID |
D019699
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| MeSH Number(s) |
D12.776.395.550.895 D12.776.543.550.895
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Thrombospondins".
Below are MeSH descriptors whose meaning is more specific than "Thrombospondins".
This graph shows the total number of publications written about "Thrombospondins" by people in this website by year, and whether "Thrombospondins" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Thrombospondins" by people in Profiles.
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THSD1 Suppresses Autophagy-Mediated Focal Adhesion Turnover by Modulating the FAK-Beclin 1 Pathway. Int J Mol Sci. 2024 Feb 10; 25(4).
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Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury. J Clin Invest. 2019 10 01; 129(10):4408-4418.
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Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nat Commun. 2019 01 08; 10(1):76.
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Intestinal Lymphatic Endothelial Cells Produce R-Spondin3. Sci Rep. 2018 Jul 16; 8(1):10719.
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The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly. Cell Physiol Biochem. 2017; 43(6):2200-2211.
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R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease. J Exp Med. 2017 Dec 04; 214(12):3507-3518.
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Highly efficient one-step scarless protein tagging by type IIS restriction endonuclease-mediated precision cloning. Biochem Biophys Res Commun. 2017 08 12; 490(1):8-16.
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Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling. Mol Cell Biol. 2016 Jan 01; 36(1):2-12.
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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature. 2013 Feb 14; 494(7436):247-50.
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Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells. J Cell Physiol. 2012 May; 227(5):1960-71.