"Thrombospondin 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.
| Descriptor ID |
D019700
|
| MeSH Number(s) |
D12.776.395.550.895.800 D12.776.543.550.895.800
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Thrombospondin 1".
Below are MeSH descriptors whose meaning is more specific than "Thrombospondin 1".
This graph shows the total number of publications written about "Thrombospondin 1" by people in this website by year, and whether "Thrombospondin 1" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 1 | 1 | 2 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 1 | 3 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
| 2009 | 2 | 1 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 3 | 4 |
| 2012 | 0 | 1 | 1 |
| 2013 | 2 | 1 | 3 |
| 2014 | 2 | 0 | 2 |
| 2016 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 3 | 0 | 3 |
| 2023 | 0 | 2 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thrombospondin 1" by people in Profiles.
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Thbs1 regulates skeletal muscle mass in a TGF?-Smad2/3-ATF4-dependent manner. Cell Rep. 2024 May 28; 43(5):114149.
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Glioblastoma remodelling of human neural circuits decreases survival. Nature. 2023 05; 617(7961):599-607.
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Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism. Int J Mol Sci. 2023 Feb 21; 24(5).
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Inhibition of thrombospondin-1 reduces glutathione activity and worsens acute liver injury during acetaminophen hepatotoxicity in mice. Toxicol Appl Pharmacol. 2020 12 15; 409:115323.
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miR-18a Inhibits BMP4 and HIF-1a Normalizing Brain Arteriovenous Malformations. Circ Res. 2020 10 09; 127(9):e210-e231.
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An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis. Neoplasia. 2020 08; 22(8):294-310.
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Thrombospondin-1 Exacerbates Acute Liver Failure and Hepatic Encephalopathy Pathology in Mice by Activating Transforming Growth Factor ?1. Am J Pathol. 2020 02; 190(2):347-357.
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Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy. Oncotarget. 2016 10 04; 7(40):65429-65440.
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Beta-adrenergic signaling promotes tumor angiogenesis and prostate cancer progression through HDAC2-mediated suppression of thrombospondin-1. Oncogene. 2017 03; 36(11):1525-1536.
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Thrombospondin-1 deficiency causes a shift from fibroproliferative to inflammatory kidney disease and delays onset of renal failure. Am J Pathol. 2014 Oct; 184(10):2687-98.