"AC133 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.
| Descriptor ID |
D000071916
|
| MeSH Number(s) |
D12.776.395.550.007 D12.776.543.550.023
|
| Concept/Terms |
AC133 Antigen- AC133 Antigen
- Antigen, AC133
- CD133 Antigen
- Antigen, CD133
- PROML1
- Prominin
- Prominin-1
- Prominin 1
- Prominin-Like PROML1
- Prominin Like PROML1
- AC133-1 Antigen
- AC133 1 Antigen
- Antigen, AC133-1
- Fudenine
|
Below are MeSH descriptors whose meaning is more general than "AC133 Antigen".
Below are MeSH descriptors whose meaning is more specific than "AC133 Antigen".
This graph shows the total number of publications written about "AC133 Antigen" by people in this website by year, and whether "AC133 Antigen" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 4 | 4 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 6 | 6 |
| 2010 | 0 | 4 | 4 |
| 2011 | 0 | 6 | 6 |
| 2012 | 0 | 5 | 5 |
| 2013 | 0 | 4 | 4 |
| 2014 | 0 | 6 | 6 |
| 2016 | 1 | 2 | 3 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "AC133 Antigen" by people in Profiles.
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A Subpopulation of Microglia Generated in the Adult Mouse Brain Originates from Prominin-1-Expressing Progenitors. J Neurosci. 2021 09 22; 41(38):7942-7953.
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Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nat Commun. 2021 05 13; 12(1):2788.
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A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019 03 12; 26(11):3061-3075.e6.
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Infusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats. Cell Physiol Biochem. 2017; 42(3):1264-1273.
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Identification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens. BMC Cancer. 2016 11 05; 16(1):853.
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Bone marrow cell characteristics associated with patient profile and cardiac performance outcomes in the LateTIME-Cardiovascular Cell Therapy Research Network (CCTRN) trial. Am Heart J. 2016 09; 179:142-50.
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CD133 does not enrich for the stem cell activity in vivo in adult mouse prostates. Stem Cell Res. 2016 05; 16(3):597-606.
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Cancer stem cell marker expression alone and in combination with microvascular invasion predicts poor prognosis in patients undergoing transplantation for hepatocellular carcinoma. Am J Surg. 2016 Aug; 212(2):238-45.
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Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells. Arterioscler Thromb Vasc Biol. 2015 Nov; 35(11):2468-77.
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Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes. Acta Neuropathol Commun. 2014 Dec 20; 2:160.