"AC133 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.
| Descriptor ID |
D000071916
|
| MeSH Number(s) |
D12.776.395.550.007 D12.776.543.550.023
|
| Concept/Terms |
AC133 Antigen- AC133 Antigen
- Antigen, AC133
- CD133 Antigen
- Antigen, CD133
- PROML1
- Prominin
- Prominin-1
- Prominin 1
- Prominin-Like PROML1
- Prominin Like PROML1
- AC133-1 Antigen
- AC133 1 Antigen
- Antigen, AC133-1
- Fudenine
|
Below are MeSH descriptors whose meaning is more general than "AC133 Antigen".
Below are MeSH descriptors whose meaning is more specific than "AC133 Antigen".
This graph shows the total number of publications written about "AC133 Antigen" by people in this website by year, and whether "AC133 Antigen" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 3 | 3 |
| 2016 | 1 | 1 | 2 |
| 2017 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "AC133 Antigen" by people in Profiles.
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CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas. Br J Cancer. 2024 Jul; 131(2):258-270.
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Infusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats. Cell Physiol Biochem. 2017; 42(3):1264-1273.
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Identification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens. BMC Cancer. 2016 11 05; 16(1):853.
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CD133 does not enrich for the stem cell activity in vivo in adult mouse prostates. Stem Cell Res. 2016 05; 16(3):597-606.
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Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes. Acta Neuropathol Commun. 2014 Dec 20; 2:160.
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Cell-surface Vimentin: A mislocalized protein for isolating csVimentin(+) CD133(-) novel stem-like hepatocellular carcinoma cells expressing EMT markers. Int J Cancer. 2015 Jul 15; 137(2):491-6.
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Cobblestone-area forming cells derived from patients with mantle cell lymphoma are enriched for CD133+ tumor-initiating cells. PLoS One. 2014; 9(4):e91042.
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Characterization of stem-like cells directly isolated from freshly resected laryngeal squamous cell carcinoma specimens. Curr Stem Cell Res Ther. 2014; 9(4):347-53.
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Lung cancer stem cell: fancy conceptual model of tumor biology or cornerstone of a forthcoming therapeutic breakthrough? J Thorac Oncol. 2014 Jan; 9(1):7-17.
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Investigating the link between molecular subtypes of glioblastoma, epithelial-mesenchymal transition, and CD133 cell surface protein. PLoS One. 2013; 8(5):e64169.