"Immunophilins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
| Descriptor ID |
D020104
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| MeSH Number(s) |
D08.811.399.325.500.400 D12.776.543.750.705.400 D12.776.827.275
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Immunophilins".
Below are MeSH descriptors whose meaning is more specific than "Immunophilins".
This graph shows the total number of publications written about "Immunophilins" by people in this website by year, and whether "Immunophilins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunophilins" by people in Profiles.
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Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS. Science. 2023 08 18; 381(6659):794-799.
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Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations. Am J Hum Genet. 2015 May 07; 96(5):832-40.
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Molecular cloning and characterization of Aspergillus nidulans cyclophilin B. Fungal Genet Biol. 1999 Jun; 27(1):55-66.
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Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. J Pharmacol Exp Ther. 1999 Jun; 289(3):1202-10.