Receptors, Leukocyte-Adhesion
"Receptors, Leukocyte-Adhesion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other and to certain substrata, e.g., the C3bi component of complement. Members of this family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1 ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells.
| Descriptor ID |
D016028
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| MeSH Number(s) |
D12.776.543.750.705.408.600
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| Concept/Terms |
Receptors, Leukocyte-Adhesion- Receptors, Leukocyte-Adhesion
- Receptors, Leukocyte Adhesion
- Leukocyte-Adhesion Receptor
- Leukocyte Adhesion Receptor
- Receptor, Leukocyte-Adhesion
- Leukocyte-Adhesion Receptor Family
- Leukocyte Adhesion Receptor Family
- Leu-CAM Receptor Family
- Family, Leu-CAM Receptor
- Leu CAM Receptor Family
- Receptor Family, Leu-CAM
- Leukocyte-Adhesion Receptors
- Leukocyte Adhesion Receptors
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Below are MeSH descriptors whose meaning is more general than "Receptors, Leukocyte-Adhesion".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Leukocyte-Adhesion".
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Below are the most recent publications written about "Receptors, Leukocyte-Adhesion" by people in Profiles.
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Interstitial leukocyte migration and immune function. Nat Immunol. 2008 Sep; 9(9):960-9.
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Compartmentalized roles for leukocytic adhesion molecules in lung inflammatory injury. J Immunol. 1995 Feb 01; 154(3):1350-63.
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Induction of intercellular adhesion molecule-1 by lipopolysaccharide in canine alveolar macrophages. Am J Respir Cell Mol Biol. 1994 Sep; 11(3):304-11.
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Reply to: neutrophil activation during cardiopulmonary bypass (J Thorac Cardiovasc Surg 1992;104:1746-8) J Thorac Cardiovasc Surg. 1993 Apr; 105(4):763.
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Expression of human CD18 in murine granulocytes and improved efficiency for infection of deficient human lymphoblasts. Hum Gene Ther. 1993 Feb; 4(1):25-34.
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An initiation codon mutation in CD18 in association with the moderate phenotype of leukocyte adhesion deficiency. J Biol Chem. 1992 Jan 15; 267(2):714-8.
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Diminished lectin-, epidermal growth factor-, complement binding domain-cell adhesion molecule-1 on neonatal neutrophils underlies their impaired CD18-independent adhesion to endothelial cells in vitro. J Immunol. 1991 May 15; 146(10):3372-9.
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Severe congenital neutropenia: clinical effects and neutrophil function during treatment with granulocyte colony-stimulating factor. J Lab Clin Med. 1991 Apr; 117(4):282-90.
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Correction of CD18-deficient lymphocytes by retrovirus-mediated gene transfer. Science. 1990 Jun 15; 248(4961):1413-6.
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Neutrophil adherence to isolated adult canine myocytes. Evidence for a CD18-dependent mechanism. J Clin Invest. 1990 May; 85(5):1497-506.