Lymphocyte Function-Associated Antigen-1
"Lymphocyte Function-Associated Antigen-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
| Descriptor ID |
D016169
|
| MeSH Number(s) |
D12.776.395.550.200.074.937 D12.776.395.550.200.625.550 D12.776.543.550.200.093.937 D12.776.543.550.200.625.550 D12.776.543.750.705.408.600.400 D12.776.543.750.705.877.550 D23.050.301.350.074.400 D23.050.301.350.625.550
|
| Concept/Terms |
Lymphocyte Function-Associated Antigen-1- Lymphocyte Function-Associated Antigen-1
- Antigen-1, Lymphocyte Function-Associated
- Lymphocyte Function Associated Antigen 1
- Integrin alphaLbeta2
- alphaLbeta2, Integrin
- Leukocyte Function Associated Antigen-1
- LFA-1
|
Below are MeSH descriptors whose meaning is more general than "Lymphocyte Function-Associated Antigen-1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Glycoproteins [D12.776.395]
- Membrane Glycoproteins [D12.776.395.550]
- Cell Adhesion Molecules [D12.776.395.550.200]
- CD11 Antigens [D12.776.395.550.200.074]
- Lymphocyte Function-Associated Antigen-1 [D12.776.395.550.200.074.937]
- Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
- Lymphocyte Function-Associated Antigen-1 [D12.776.395.550.200.625.550]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Cell Adhesion Molecules [D12.776.543.550.200]
- CD11 Antigens [D12.776.543.550.200.093]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.550.200.093.937]
- Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.550.200.625.550]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Integrins [D12.776.543.750.705.408]
- Receptors, Leukocyte-Adhesion [D12.776.543.750.705.408.600]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.408.600.400]
- Receptors, Lymphocyte Homing [D12.776.543.750.705.877]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.877.550]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Cell Adhesion Molecules [D23.050.301.350]
- CD11 Antigens [D23.050.301.350.074]
- Lymphocyte Function-Associated Antigen-1 [D23.050.301.350.074.400]
- Receptors, Lymphocyte Homing [D23.050.301.350.625]
- Lymphocyte Function-Associated Antigen-1 [D23.050.301.350.625.550]
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Function-Associated Antigen-1".
This graph shows the total number of publications written about "Lymphocyte Function-Associated Antigen-1" by people in this website by year, and whether "Lymphocyte Function-Associated Antigen-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 |
| 1996 | 1 | 0 | 1 |
| 1997 | 5 | 2 | 7 |
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 2 | 0 | 2 |
| 2001 | 1 | 1 | 2 |
| 2002 | 1 | 4 | 5 |
| 2003 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 3 | 0 | 3 |
| 2010 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2022 | 2 | 0 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Lymphocyte Function-Associated Antigen-1" by people in Profiles.
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A bifurcation concept for B-lymphoid/plasmacytoid dendritic cells with largely fluctuating transcriptome dynamics. Cell Rep. 2022 08 30; 40(9):111260.
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LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade. J Clin Invest. 2022 07 01; 132(13).
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LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease. J Ocul Pharmacol Ther. 2017 Jan/Feb; 33(1):5-12.
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NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing. J Cell Biol. 2016 Dec 19; 215(6):875-889.
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Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 04; 14(2):207-15.
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B-Raf regulation of integrin a4?1-mediated resistance to shear stress through changes in cell spreading and cytoskeletal association in T cells. J Biol Chem. 2014 Aug 15; 289(33):23141-23153.
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Adhesion shapes T cells for prompt and sustained T-cell receptor signalling. EMBO J. 2010 Dec 01; 29(23):4035-47.
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Cord blood natural killer cells exhibit impaired lytic immunological synapse formation that is reversed with IL-2 exvivo expansion. J Immunother. 2010 Sep; 33(7):684-96.
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2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1. J Biol Chem. 2010 Oct 22; 285(43):32860-32868.
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Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization. J Immunol. 2010 Sep 01; 185(5):2918-26.