"Integrin alpha4beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Descriptor ID |
D039041
|
MeSH Number(s) |
D12.776.395.550.200.625.347 D12.776.543.550.200.625.347 D12.776.543.750.705.408.530.500 D12.776.543.750.705.408.850.299 D12.776.543.750.705.877.347 D23.050.301.350.625.347
|
Concept/Terms |
Integrin alpha4beta1- Integrin alpha4beta1
- alpha4beta1, Integrin
- VLA-4
- Integrin alpha(4)beta(1)
- alpha4beta1 Integrin
- Integrin, alpha4beta1
- Very Late Activation Antigen-4
- Very Late Activation Antigen 4
- Very Late Antigen-4
- Antigen-4, Very Late
- Late Antigen-4, Very
- Very Late Antigen 4
- CD49d-CD29
- Integrin Heterodimer alpha4beta1
- Heterodimer alpha4beta1, Integrin
- alpha4beta1, Integrin Heterodimer
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha4beta1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Glycoproteins [D12.776.395]
- Membrane Glycoproteins [D12.776.395.550]
- Cell Adhesion Molecules [D12.776.395.550.200]
- Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
- Integrin alpha4beta1 [D12.776.395.550.200.625.347]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Cell Adhesion Molecules [D12.776.543.550.200]
- Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
- Integrin alpha4beta1 [D12.776.543.550.200.625.347]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Integrins [D12.776.543.750.705.408]
- Receptors, Fibronectin [D12.776.543.750.705.408.530]
- Integrin alpha4beta1 [D12.776.543.750.705.408.530.500]
- Receptors, Very Late Antigen [D12.776.543.750.705.408.850]
- Integrin alpha4beta1 [D12.776.543.750.705.408.850.299]
- Receptors, Lymphocyte Homing [D12.776.543.750.705.877]
- Integrin alpha4beta1 [D12.776.543.750.705.877.347]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Cell Adhesion Molecules [D23.050.301.350]
- Receptors, Lymphocyte Homing [D23.050.301.350.625]
- Integrin alpha4beta1 [D23.050.301.350.625.347]
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha4beta1".
This graph shows the total number of publications written about "Integrin alpha4beta1" by people in this website by year, and whether "Integrin alpha4beta1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
1998 | 0 | 1 | 1 |
2001 | 0 | 1 | 1 |
2002 | 0 | 2 | 2 |
2003 | 1 | 0 | 1 |
2005 | 1 | 1 | 2 |
2007 | 1 | 0 | 1 |
2008 | 0 | 1 | 1 |
2009 | 1 | 0 | 1 |
2013 | 2 | 2 | 4 |
2014 | 2 | 1 | 3 |
2015 | 1 | 1 | 2 |
2018 | 2 | 0 | 2 |
2020 | 0 | 1 | 1 |
2021 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Integrin alpha4beta1" by people in Profiles.
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CC16 Binding to a4?1 Integrin Protects against Mycoplasma pneumoniae Infection. Am J Respir Crit Care Med. 2021 06 01; 203(11):1410-1418.
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An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes. J Immunol. 2020 11 15; 205(10):2806-2820.
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Magnetic Resonance Imaging of Atherosclerotic Plaque at Clinically Relevant Field Strengths (1T) by Targeting the Integrin a4?1. Sci Rep. 2018 02 27; 8(1):3733.
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Functional and clinical relevance of VLA-4 (CD49d/CD29) in ibrutinib-treated chronic lymphocytic leukemia. J Exp Med. 2018 02 05; 215(2):681-697.
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CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia. J Immunol. 2015 Dec 01; 195(11):5380-92.
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Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5888-95.
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VCAM-1 on peritoneum and a4?1 integrin in endometrium and their implications in endometriosis. Int J Gynecol Pathol. 2015 Jan; 34(1):85-9.
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Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition. Oncotarget. 2014 Oct 15; 5(19):8947-58.
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B-Raf regulation of integrin a4?1-mediated resistance to shear stress through changes in cell spreading and cytoskeletal association in T cells. J Biol Chem. 2014 Aug 15; 289(33):23141-23153.
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Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-?B mediates chemoresistance. Blood. 2014 Apr 24; 123(17):2691-702.