"Integrin alpha1beta1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
| Descriptor ID |
D039222
|
| MeSH Number(s) |
D12.776.543.750.685.100 D12.776.543.750.705.408.850.099 D12.776.543.750.705.876.249
|
| Concept/Terms |
Integrin alpha1beta1- Integrin alpha1beta1
- alpha1beta1, Integrin
- VLA-1
- Integrin alpha(1)beta(1)
- CD49a-CD29
- alpha1beta1 Integrin
- Integrin, alpha1beta1
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha1beta1".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha1beta1".
This graph shows the total number of publications written about "Integrin alpha1beta1" by people in this website by year, and whether "Integrin alpha1beta1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Integrin alpha1beta1" by people in Profiles.
-
Type XVIII collagen is essential for survival during acute liver injury in mice. Dis Model Mech. 2013 Jul; 6(4):942-51.
-
Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressor. Exp Cell Res. 2008 Nov 01; 314(18):3292-305.
-
Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8811-8.
-
Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin. J Clin Invest. 2005 Oct; 115(10):2801-10.
-
Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironment. Cancer Res. 2003 Dec 01; 63(23):8312-7.
-
Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy. Am J Pathol. 2000 Nov; 157(5):1649-59.
-
Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo. J Cell Biol. 1998 Jul 27; 142(2):587-94.
-
Loss of alpha 1 beta 1 and reduced expression of other beta 1 integrins and CAM in lung adenocarcinoma compared with pneumocytes. J Surg Oncol. 1994 Jul; 56(3):198-208.