Matrix Metalloproteinase 14
"Matrix Metalloproteinase 14" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
| Descriptor ID |
D053511
|
| MeSH Number(s) |
D08.811.277.656.300.480.525.300.500 D08.811.277.656.675.374.525.300.500
|
| Concept/Terms |
Matrix Metalloproteinase 14- Matrix Metalloproteinase 14
- Metalloproteinase 14, Matrix
- Membrane-Type Matrix Metalloproteinase 1
- Membrane Type Matrix Metalloproteinase 1
- MMP-14 Metalloproteinase
- MMP 14 Metalloproteinase
- Metalloproteinase, MMP-14
- MT1-MMP
- MMP14 Metalloproteinase
- Metalloproteinase, MMP14
- MT-MMP-1
- MT1-Matrix Metalloproteinase
- MT1 Matrix Metalloproteinase
- Metalloproteinase, MT1-Matrix
- Membrane-Type 1 Matrix Metalloproteinase
- Membrane Type 1 Matrix Metalloproteinase
- MMP-X1 Protein
- MMP X1 Protein
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Below are MeSH descriptors whose meaning is more general than "Matrix Metalloproteinase 14".
Below are MeSH descriptors whose meaning is more specific than "Matrix Metalloproteinase 14".
This graph shows the total number of publications written about "Matrix Metalloproteinase 14" by people in this website by year, and whether "Matrix Metalloproteinase 14" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 2 | 3 |
| 2007 | 1 | 2 | 3 |
| 2009 | 2 | 0 | 2 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Matrix Metalloproteinase 14" by people in Profiles.
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Rosavin Ameliorates Hepatic Inflammation and Fibrosis in the NASH Rat Model via Targeting Hepatic Cell Death. Int J Mol Sci. 2022 Sep 05; 23(17).
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Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma. Mol Cancer Ther. 2022 06 01; 21(6):903-913.
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Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension. Matrix Biol. 2021 05; 99:18-42.
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Membrane-bound MMP-14 protease-activatable adeno-associated viral vectors for gene delivery to pancreatic tumors. Gene Ther. 2022 04; 29(3-4):138-146.
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Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma. Clin Cancer Res. 2020 11 15; 26(22):6039-6050.
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Preclinical Efficacy of Endoglin-Targeting Antibody-Drug Conjugates for the Treatment of Ewing Sarcoma. Clin Cancer Res. 2019 04 01; 25(7):2228-2240.
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Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells. Dev Cell. 2017 10 23; 43(2):186-197.e7.
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MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-? signaling. Mol Cancer Res. 2011 Oct; 9(10):1294-304.
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MT1-MMP-mediated basement membrane remodeling modulates renal development. Exp Cell Res. 2010 Oct 15; 316(17):2993-3005.
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Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events. Blood. 2010 Jun 24; 115(25):5259-69.