Autophagy-Related Protein-1 Homolog
"Autophagy-Related Protein-1 Homolog" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates.
| Descriptor ID |
D000071189
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.108 D12.644.360.081 D12.776.094.438 D12.776.476.078
|
| Concept/Terms |
Autophagy-Related Protein-1 Homolog- Autophagy-Related Protein-1 Homolog
- Autophagy Related Protein 1 Homolog
- Serine-Threonine Protein Kinase ULK1
- Serine Threonine Protein Kinase ULK1
- Unc-51 Like Autophagy Activating Kinase 1
- Unc 51 Like Autophagy Activating Kinase 1
- ULK1 Protein
- Unc-51-Like Kinase 1
- Unc 51 Like Kinase 1
|
Below are MeSH descriptors whose meaning is more general than "Autophagy-Related Protein-1 Homolog".
Below are MeSH descriptors whose meaning is more specific than "Autophagy-Related Protein-1 Homolog".
This graph shows the total number of publications written about "Autophagy-Related Protein-1 Homolog" by people in this website by year, and whether "Autophagy-Related Protein-1 Homolog" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Autophagy-Related Protein-1 Homolog" by people in Profiles.
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Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer. Elife. 2024 Aug 30; 13.
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ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Nat Cancer. 2021 05; 2(5):503-514.
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Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling. Oncogene. 2021 03; 40(9):1690-1705.
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Rapamycin Eyedrops Increased CD4+Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. Int J Mol Sci. 2020 Nov 24; 21(23).
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TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKK?/VPS34 pathway. Nat Commun. 2019 12 10; 10(1):5630.
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SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity. Cell Death Differ. 2020 01; 27(1):329-344.
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TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018 07 18; 9(1):2812.
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Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING. Cell Rep. 2018 04 24; 23(4):1112-1123.
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Huntingtin functions as a scaffold for selective macroautophagy. Nat Cell Biol. 2015 Mar; 17(3):262-75.