STAT Transcription Factors
"STAT Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.
| Descriptor ID |
D050791
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| MeSH Number(s) |
D12.644.360.024.342 D12.776.157.057.186 D12.776.476.024.430 D12.776.930.840
|
| Concept/Terms |
STAT Transcription Factors- STAT Transcription Factors
- Transcription Factors, STAT
- STAT (Signal Transducers and Activators of Transcription) Proteins
|
Below are MeSH descriptors whose meaning is more general than "STAT Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "STAT Transcription Factors".
This graph shows the total number of publications written about "STAT Transcription Factors" by people in this website by year, and whether "STAT Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 3 | 0 | 3 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2019 | 2 | 0 | 2 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "STAT Transcription Factors" by people in Profiles.
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JAK/STAT defects and immune dysregulation, and guiding therapeutic choices. Immunol Rev. 2024 03; 322(1):311-328.
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Human diseases caused by impaired signal transducer and activator of transcription and Janus kinase signaling. Curr Opin Pediatr. 2019 12; 31(6):843-850.
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JAK/STAT proteins and their biological impact on NK cell development and function. Mol Immunol. 2019 11; 115:21-30.
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Inflammatory breast cancer biology: the tumour microenvironment is key. Nat Rev Cancer. 2018 08; 18(8):485-499.
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JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. Leukemia. 2017 12; 31(12):2568-2576.
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Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan. Cell Host Microbe. 2016 Feb 10; 19(2):240-53.
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The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol. 2013 Jul; 14(7):732-40.
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STAT signaling in mammary gland differentiation, cell survival and tumorigenesis. Mol Cell Endocrinol. 2014 Jan 25; 382(1):560-569.
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The role of JAK pathway dysregulation in the pathogenesis and treatment of acute myeloid leukemia. Clin Cancer Res. 2013 Jan 15; 19(2):327-35.
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Enhanced TLR-induced NF-?B signaling and type I interferon responses in NLRC5 deficient mice. Cell Res. 2012 May; 22(5):822-35.