STAT5 Transcription Factor
"STAT5 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.
| Descriptor ID |
D050799
|
| MeSH Number(s) |
D12.644.360.024.342.500 D12.776.157.057.186.500 D12.776.476.024.430.500 D12.776.930.840.500
|
| Concept/Terms |
STAT5 Transcription Factor- STAT5 Transcription Factor
- Factor, STAT5 Transcription
- Transcription Factor, STAT5
- STAT5 Protein
- Signal Transducer and Activator of Transcription 5
STAT5b Transcription Factor- STAT5b Transcription Factor
- Transcription Factor, STAT5b
- STAT5beta Protein
- STAT5b Protein
- Signal Transducer and Activator of Transcription 5B
STAT5a Transcription Factor- STAT5a Transcription Factor
- Transcription Factor, STAT5a
- Mammary Gland Factor
- Signal Transducer and Activator of Transcription 5A
- STAT5alpha Protein
- STAT5a Protein
- Mammary Gland-Specific Nuclear Factor
- Mammary Gland Specific Nuclear Factor
|
Below are MeSH descriptors whose meaning is more general than "STAT5 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT5 Transcription Factor".
This graph shows the total number of publications written about "STAT5 Transcription Factor" by people in this website by year, and whether "STAT5 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 4 | 4 |
| 1999 | 0 | 5 | 5 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 6 | 6 |
| 2003 | 0 | 8 | 8 |
| 2004 | 0 | 4 | 4 |
| 2005 | 0 | 3 | 3 |
| 2006 | 3 | 3 | 6 |
| 2007 | 2 | 4 | 6 |
| 2008 | 3 | 2 | 5 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 5 | 4 | 9 |
| 2012 | 6 | 4 | 10 |
| 2013 | 3 | 2 | 5 |
| 2014 | 1 | 4 | 5 |
| 2015 | 2 | 1 | 3 |
| 2016 | 1 | 4 | 5 |
| 2017 | 3 | 1 | 4 |
| 2018 | 3 | 0 | 3 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 2 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 2 | 2 | 4 |
| 2023 | 2 | 1 | 3 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "STAT5 Transcription Factor" by people in Profiles.
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STAT5B mutations in myeloid neoplasms differ by disease subtypes but characterize a subset of chronic myeloid neoplasms with eosinophilia and/or basophilia. Haematologica. 2024 06 01; 109(6):1825-1835.
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Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma. Cancer Biol Med. 2023 06 27; 20(8).
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T-Cell Prolymphocytic Leukemia With t(X;14)(q28;q11.2): A Clinicopathologic Study of 15 Cases. Am J Clin Pathol. 2023 04 04; 159(4):325-336.
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STAT5b: A master regulator of key biological pathways. Front Immunol. 2022; 13:1025373.
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STAT5 confers lactogenic properties in breast tumorigenesis and restricts metastatic potential. Oncogene. 2022 11; 41(48):5214-5222.
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STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis. J Allergy Clin Immunol. 2022 10; 150(4):931-946.
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ABT199/venetoclax potentiates the cytotoxicity of alkylating agents and fludarabine in acute myeloid leukemia cells. Oncotarget. 2022; 13:319-330.
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Phenotypic and Functional Plasticity of CXCR6+ Peripheral Blood NK Cells. Front Immunol. 2021; 12:810080.
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Aberrantly low STAT3 and STAT5 responses are associated with poor outcome and an inflammatory gene expression signature in pediatric acute myeloid leukemia. Clin Transl Oncol. 2021 Oct; 23(10):2141-2154.
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JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation. Blood. 2020 08 06; 136(6):657-668.