STAT3 Transcription Factor
"STAT3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
| Descriptor ID |
D050796
|
| MeSH Number(s) |
D12.644.360.024.342.300 D12.776.157.057.186.300 D12.776.476.024.430.300 D12.776.930.840.300
|
| Concept/Terms |
STAT3 Transcription Factor- STAT3 Transcription Factor
- Transcription Factor, STAT3
- LIF-Response Factor
- LIF Response Factor
- Acute-Phase Response Factor
- Acute Phase Response Factor
- Response Factor, Acute-Phase
- APRF Transcription Factor
- Transcription Factor, APRF
- Signal Transducer and Activator of Transcription 3
- IL6-Response Factor
- IL6 Response Factor
- STAT3 Protein
STAT3b Transcription Factor- STAT3b Transcription Factor
- Transcription Factor, STAT3b
- Stat3beta Transcription Factor
- Transcription Factor, Stat3beta
STAT3a Transcription Factor- STAT3a Transcription Factor
- Transcription Factor, STAT3a
- Stat3alpha Transcription Factor
- Transcription Factor, Stat3alpha
|
Below are MeSH descriptors whose meaning is more general than "STAT3 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT3 Transcription Factor".
This graph shows the total number of publications written about "STAT3 Transcription Factor" by people in this website by year, and whether "STAT3 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 4 | 4 |
| 2004 | 0 | 4 | 4 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 2 | 2 |
| 2007 | 3 | 2 | 5 |
| 2008 | 6 | 4 | 10 |
| 2009 | 6 | 6 | 12 |
| 2010 | 1 | 2 | 3 |
| 2011 | 3 | 5 | 8 |
| 2012 | 6 | 3 | 9 |
| 2013 | 6 | 3 | 9 |
| 2014 | 5 | 1 | 6 |
| 2015 | 10 | 3 | 13 |
| 2016 | 7 | 4 | 11 |
| 2017 | 5 | 2 | 7 |
| 2018 | 5 | 2 | 7 |
| 2019 | 5 | 3 | 8 |
| 2020 | 7 | 0 | 7 |
| 2021 | 4 | 1 | 5 |
| 2022 | 0 | 7 | 7 |
| 2023 | 1 | 1 | 2 |
| 2024 | 2 | 1 | 3 |
| 2025 | 5 | 3 | 8 |
| 2026 | 2 | 0 | 2 |
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click here.
Below are the most recent publications written about "STAT3 Transcription Factor" by people in Profiles.
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Imbalance Between CD44 and STAT3 Enhances Spheroid Viability and Impairs Pembrolizumab Response in Urothelial Cancer. Anticancer Res. 2026 May; 46(5):2445-2453.
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Disease-causing STAT3 variants can be discriminated by a functional flow cytometry test. Pediatr Allergy Immunol. 2026 Feb; 37(2):e70300.
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Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal-Associated Invariant T (MAIT) Cell Function. Immunology. 2026 05; 178(1):97-108.
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STAT3 Inhibition to Treat Ulcerative Colitis-Associated Colorectal Cancer. Int J Mol Sci. 2025 Nov 06; 26(21).
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Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells. Stem Cell Reports. 2025 Nov 11; 20(11):102692.
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Case Report: Dual molecular diagnosis of gain-of-function STAT1 mutation and regulatory STAT3 variant in a patient with a hyper-IgE-like phenotype. Front Immunol. 2025; 16:1646761.
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Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity. Nature. 2025 07; 643(8070):219-229.
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Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity. Front Immunol. 2025; 16:1575181.
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Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infection. Cell Rep. 2025 Apr 22; 44(4):115438.
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Macrophage-mediated IL-6 signaling drives ryanodine receptor-2 calcium leak in postoperative atrial fibrillation. J Clin Invest. 2025 May 01; 135(9).