STAT4 Transcription Factor
"STAT4 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-12 in T-LYMPHOCYTES. Stat4 is an important signaling molecule for differentiation in TH1 CELLS.
| Descriptor ID |
D050797
|
| MeSH Number(s) |
D12.644.360.024.342.400 D12.776.157.057.186.400 D12.776.476.024.430.400 D12.776.930.840.400
|
| Concept/Terms |
STAT4 Transcription Factor- STAT4 Transcription Factor
- Transcription Factor, STAT4
- Signal Transducer and Activator of Transcription 4
- STAT4 Protein
- Transcription Factor STAT4
|
Below are MeSH descriptors whose meaning is more general than "STAT4 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT4 Transcription Factor".
This graph shows the total number of publications written about "STAT4 Transcription Factor" by people in this website by year, and whether "STAT4 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 2 | 2 |
| 2014 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "STAT4 Transcription Factor" by people in Profiles.
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STAT4 Regulates the CD8+ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr-/- Mice. J Immunol. 2017 11 15; 199(10):3453-3465.
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STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J Virol. 2014 Sep 01; 88(17):9655-72.
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Deregulation in STAT signaling is important for cutaneous T-cell lymphoma (CTCL) pathogenesis and cancer progression. Cell Cycle. 2014; 13(21):3331-5.
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TIP: a probabilistic method for identifying transcription factor target genes from ChIP-seq binding profiles. Bioinformatics. 2011 Dec 01; 27(23):3221-7.
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Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates. Immunity. 2011 Jul 22; 35(1):45-58.
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Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans. Ann Rheum Dis. 2010 Apr; 69(4):625-6.
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Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines. Arthritis Rheum. 2009 Dec; 60(12):3794-806.
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The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype. Hum Mol Genet. 2009 Jun 01; 18(11):2071-7.
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Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma. Blood. 2008 Apr 15; 111(8):4173-83.
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STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med. 2007 Sep 06; 357(10):977-86.