Shc Signaling Adaptor Proteins
"Shc Signaling Adaptor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of signaling adaptor proteins that contain SRC HOMOLOGY DOMAINS. Many members of this family are involved in transmitting signals from CELL SURFACE RECEPTORS to MITOGEN-ACTIVATED PROTEIN KINASES.
| Descriptor ID |
D055765
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| MeSH Number(s) |
D12.644.360.024.330 D12.776.157.057.162 D12.776.476.024.424
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Shc Signaling Adaptor Proteins".
Below are MeSH descriptors whose meaning is more specific than "Shc Signaling Adaptor Proteins".
This graph shows the total number of publications written about "Shc Signaling Adaptor Proteins" by people in this website by year, and whether "Shc Signaling Adaptor Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Shc Signaling Adaptor Proteins" by people in Profiles.
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Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity. Genes (Basel). 2020 10 25; 11(11).
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SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):E6068-77.
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Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks. Nat Commun. 2014 Dec 15; 5:5811.
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Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli. Nat Struct Mol Biol. 2013 May; 20(5):620-7.
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Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST). Chin J Cancer. 2013 Feb; 32(2):75-83.
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Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-? (TGF-?). J Biol Chem. 2011 Dec 23; 286(51):44023-44034.
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Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. J Clin Invest. 2010 Mar; 120(3):778-90.
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Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2). Biochem J. 2008 Dec 01; 416(2):189-99.
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Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action. Mol Endocrinol. 2006 Mar; 20(3):491-502.
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RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors. Oncogene. 2005 Sep 15; 24(41):6303-13.