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Udhaya Kumar Siva Kumar

TitlePostdoc Fellows and Associates
InstitutionBaylor College of Medicine
DepartmentPostDoc
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ORCID ORCID Icon0000-0002-6639-3746 Additional info
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    Collapse Biography 
    Collapse education and training
    Vellore Institute of Technology, IndiaPh.D.08/2022Integrative Genomics and Bioinformatics
    Chungnam National University, South KoreaRes.06/2018Neurodevelopmental Genetics
    Collapse awards and honors
    2023 - 2024Frank Belton Kimmel and Sandra Kimmel Endowed Post-Doctoral Trainee Fellowship for Diabetes Research, Baylor College of Medicine, USA
    2019 - 2022Senior Research Fellowship (ICMR, India), Vellore Institute of Technology (VIT), India

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abduljaleel Z, Melebari S, Athar M, Dehlawi S, Udhaya Kumar S, Aziz SA, Dannoun AI, Malik SM, Thasleem J, George Priya Doss C. SARS-CoV-2 vaccine breakthrough infections (VBI) by Omicron variant (B.1.1.529) and consequences in structural and functional impact. Cell Signal. 2023 09; 109:110798. PMID: 37423342.
      Citations: 3     Fields:    Translation:HumansCells
    2. Balasundaram A, Ramireddy S, S UK, D TK, Tayubi IA, Zayed H, C GPD. A new horizon in the phosphorylated sites of AGA: the structural impact of C163S mutation in aspartylglucosaminuria through molecular dynamics simulation. J Biomol Struct Dyn. 2023 Jun 19; 1-12. PMID: 37334725.
      Citations:    Fields:    
    3. Chandrasekaran FP, Vishal A, Arora U, Kumar S U, George C PD, Nelson EJR. Molecular dynamics simulations corroborate recombinant expression studies carried out on three aIIb ?-propeller mutations reported in Indian Glanzmann thrombasthenia patients. J Cell Biochem. 2023 07; 124(7):989-1001. PMID: 37210732.
      Citations:    Fields:    Translation:HumansCells
    4. Sundarrajan S, Venkatesan A, Kumar S U, Gopikrishnan M, Tayubi IA, Aditya M, Siddaiah GB, George Priya Doss C, Zayed H. Exome sequence analysis of rare frequency variants in Late-Onset Alzheimer Disease. Metab Brain Dis. 2023 08; 38(6):2025-2036. PMID: 37162726; PMCID: PMC10348954.
      Citations:    Fields:    Translation:Humans
    5. Dey H, Vasudevan K, Doss C GP, Kumar SU, El Allali A, Alsamman AM, Zayed H. Integrated gene network analysis sheds light on understanding the progression of Osteosarcoma. Front Med (Lausanne). 2023; 10:1154417. PMID: 37081847; PMCID: PMC10110863.
      Citations: 1     
    6. Balasundaram A, Kumar S U, D TK, Anil Dedge A, R G, K SS, R S, C GPD. The targeted next-generation sequence revealed SMAD4, AKT1, and TP53 mutations from circulating cell-free DNA of breast cancer and its effect on protein structure - A computational approach. J Biomol Struct Dyn. 2023; 41(24):15584-15597. PMID: 37011004.
      Citations:    Fields:    
    7. Anusha M, Tejaswini V, Udhaya Kumar S, Prashantha CN, Vasudevan K, George Priya Doss C. Gene network interaction analysis to elucidate the antimicrobial resistance mechanisms in the Clostridiumdifficile. Microb Pathog. 2023 May; 178:106083. PMID: 36958645.
      Citations:    Fields:    Translation:Cells
    8. Madhana Priya N, Balasundaram A, Sidharth Kumar N, Udhaya Kumar S, Thirumal Kumar D, Magesh R, Zayed H, George Priya Doss C. Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach. Adv Protein Chem Struct Biol. 2023; 135:97-124. PMID: 37061342.
      Citations: 1     Fields:    Translation:HumansCells
    9. Datta A, R HC, Udhaya Kumar S, Vasudevan K, Thirumal Kumar D, Zayed H, George Priya Doss C. Molecular characterization of circadian gene expression and its correlation with survival percentage in colorectal cancer patients. Adv Protein Chem Struct Biol. 2023; 137:161-180. PMID: 37709374.
      Citations:    Fields:    Translation:Humans
    10. Munnangi AK, UdhayaKumar S, Ravi V, Sekaran R, Kannan S. Survival study on deep learning techniques for IoT enabled smart healthcare system. Health Technol (Berl). 2023; 13(2):215-228. PMID: 36818549; PMCID: PMC9918340.
      Citations: 1     
    11. D'costa M, Bothe A, Das S, Udhaya Kumar S, Gnanasambandan R, George Priya Doss C. CDK regulators-Cell cycle progression or apoptosis-Scenarios in normal cells and cancerous cells. Adv Protein Chem Struct Biol. 2023; 135:125-177. PMID: 37061330.
      Citations: 2     Fields:    Translation:Humans
    12. Datta A, Udhaya Kumar S, D'costa M, Bothe A, Thirumal Kumar D, Zayed H, George Priya Doss C. Identification of dysregulated canonical pathways associated with pathogenesis and progression of Amyotrophic Lateral Sclerosis-An integrated bioinformatics approach. Adv Protein Chem Struct Biol. 2023; 134:21-52. PMID: 36858735.
      Citations:    Fields:    Translation:HumansCells
    13. Gharemirshamloo FR, Majumder R, Kumar S U, Doss C GP, Bamdad K, Frootan F, Un C. Effects of the pathological E200K mutation on human prion protein: A computational screening and molecular dynamics approach. J Cell Biochem. 2023 02; 124(2):254-265. PMID: 36565210.
      Citations:    Fields:    Translation:HumansCells
    14. R HC, Kumar S U, R G, Naayanan PJ, Sathiyarajeswaren P, Devi MSS, K SS, Doss C GP. An integrated investigation of structural and pathway alteration caused by PIK3CA and TP53 mutations identified in cfDNA of metastatic breast cancer. J Cell Biochem. 2023 02; 124(2):188-204. PMID: 36563059.
      Citations:    Fields:    Translation:Humans
    15. G K, Vasudevan K, Dey H, Kausar T, Udhaya Kumar S, Thirumal Kumar D, Zayed H, George Priya Doss C. Elucidating the mechanism of antimicrobial resistance in Mycobacterium tuberculosis using gene interaction networks. Adv Protein Chem Struct Biol. 2023; 134:53-74. PMID: 36858742.
      Citations: 1     Fields:    Translation:Cells
    16. Kapoor L, Udhaya Kumar S, De S, Vijayakumar S, Kapoor N, Ashok Kumar SK, Priya Doss C G, Ramamoorthy S. Multispectroscopic, virtual and in vivo insights into the photoaging defense mediated by the natural food colorant bixin. Food Funct. 2022 Dec 12. PMID: 36503930.
      Citations:    Fields:    
    17. Vasudevan K, Udhaya Kumar S, Mithun A, Raghavendra B, George Priya Doss C. Structure-based virtual screening to identify potential lipase inhibitors to reduce lipid storage in Wolman disorder. Adv Protein Chem Struct Biol. 2023; 133:351-363. PMID: 36707205.
      Citations:    Fields:    Translation:Humans
    18. Almaghrbi H, Elkardawy R, Udhaya Kumar S, Kuttikrishnan S, Abunada T, Kashyap MK, Ahmad A, Uddin S, George Priya Doss C, Zayed H. Analysis of signaling cascades from myeloma cells treated with pristimerin. Adv Protein Chem Struct Biol. 2023; 134:147-174. PMID: 36858733.
      Citations: 1     Fields:    Translation:HumansCells
    19. Madhana Priya N, Udhaya Kumar S, Thirumal Kumar D, Magesh R, Siva R, Gnanasambandan R, George Priya Doss C. Deciphering the effect of mutations in MMAA protein causing methylmalonic acidemia-A computational approach. Adv Protein Chem Struct Biol. 2022; 132:199-220. PMID: 36088076.
      Citations:    
    20. Thirumal Kumar D, Shaikh N, Udhaya Kumar S, George Priya Doss C. Computational and structural investigation of Palmitoyl-Protein Thioesterase 1 (PPT1) protein causing Neuronal Ceroid Lipofuscinoses (NCL). Adv Protein Chem Struct Biol. 2022; 132:89-109. PMID: 36088080.
      Citations:    
    21. Tayubi IA, Kumar S U, Doss C GP. Identification of potential inhibitors, conformational dynamics, and mechanistic insights into mutant Kirsten rat sarcoma virus (G13D) driven cancers. J Cell Biochem. 2022 09; 123(9):1467-1480. PMID: 35842839.
      Citations:    
    22. Udhaya Kumar S, Datta A, Gnanasambandan R, Younes S, Medha T, Siva R, George Priya Doss C, Zayed H. Investigation of differentially expressed genes and dysregulated pathways involved in multiple sclerosis. Adv Protein Chem Struct Biol. 2022; 131:235-259. PMID: 35871892.
      Citations:    
    23. Udhaya Kumar S, Balasundaram A, Anu Preethi V, Chatterjee S, Kameshwari Gollakota GV, Kashyap MK, George Priya Doss C, Zayed H. Integrative ontology and pathway-based approach identifies distinct molecular signatures in transcriptomes of esophageal squamous cell carcinoma. Adv Protein Chem Struct Biol. 2022; 131:177-206. PMID: 35871890.
      Citations:    
    24. Hephzibah Cathryn R, Udhaya Kumar S, Younes S, Zayed H, George Priya Doss C. A review of bioinformatics tools and web servers in different microarray platforms used in cancer research. Adv Protein Chem Struct Biol. 2022; 131:85-164. PMID: 35871897.
      Citations:    
    25. Kumar S U, Balasundaram A, Cathryn R H, Varghese RP, R S, R G, Younes S, Zayed H, Doss C GP. Whole-exome sequencing analysis of NSCLC reveals the pathogenic missense variants from cancer-associated genes. Comput Biol Med. 2022 09; 148:105701. PMID: 35753820.
      Citations:    
    26. Thirumal Kumar D, Udhaya Kumar S, Jain N, Sowmya B, Balsekar K, Siva R, Kamaraj B, Sidenna M, George Priya Doss C, Zayed H. Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein interface. Adv Protein Chem Struct Biol. 2022; 130:375-397. PMID: 35534113.
      Citations:    
    27. Udhaya Kumar S, Kamaraj B, Varghese RP, Preethi VA, Bithia R, George Priya Doss C. Mutations in G6PC2 gene with increased risk for development of type 2 diabetes: Understanding via computational approach. Adv Protein Chem Struct Biol. 2022; 130:351-373. PMID: 35534112.
      Citations:    
    28. Balasundaram A, Udhaya Kumar S, George Priya Doss C. A computational model revealing the immune-related hub genes and key pathways involved in rheumatoid arthritis (RA). Adv Protein Chem Struct Biol. 2022; 129:247-273. PMID: 35305721.
      Citations:    
    29. Thirumal Kumar D, Shree Devi MS, Udhaya Kumar S, Sherlin A, Mathew A, Lakshmipriya M, Sathiyarajeswaran P, Gnanasambandan R, Siva R, Magesh R, George Priya Doss C. Understanding the activating mechanism of the immune system against COVID-19 by Traditional Indian Medicine: Network pharmacology approach. Adv Protein Chem Struct Biol. 2022; 129:275-379. PMID: 35305722; PMCID: PMC8798878.
      Citations:    
    30. Mallina H, Elumalai R, F D Paul S, George Priya Doss C, Udhaya Kumar S, Ramanathan G. Computational validation of ABCB1 gene polymorphism and its effect on tacrolimus dose concentration/levels in renal transplant individuals of South India. Comput Biol Med. 2021 12; 139:104971. PMID: 34735949.
      Citations:    
    31. Kumar SU, Priya Doss CG. Computational investigation to identify potent inhibitors of the GTPase-Kirsten RAt sarcoma virus (K-Ras) mutants G12C and G12D. Comput Biol Med. 2021 12; 139:104946. PMID: 34715554.
      Citations:    
    32. Vasudevan K, Thirumal Kumar D, Udhaya Kumar S, Saleem A, Nagasundaram N, Siva R, Tayubi IA, George Priya Doss C, Zayed H. A computational overview on phylogenetic characterization, pathogenic mutations, and drug targets for Ebola virus disease. Curr Opin Pharmacol. 2021 12; 61:28-35. PMID: 34563987.
      Citations:    
    33. Kumar SU, Rajan B, Kumar DT, Cathryn RH, Das S, Zayed H, Emmanuel Jebaraj Walter C, Ramanathan G, Priya Doss C G. Comparison of potential inhibitors and targeting fat mass and obesity-associated protein causing diabesity through docking and molecular dynamics strategies. J Cell Biochem. 2021 11; 122(11):1625-1638. PMID: 34289159.
      Citations:    
    34. Varghese R, S UK, C GPD, Ramamoorthy S. Unraveling the versatility of CCD4: Metabolic engineering, transcriptomic and computational approaches. Plant Sci. 2021 Sep; 310:110991. PMID: 34315605.
      Citations:    
    35. Kumar SU, Priya Doss CG. Residue interaction networks of K-Ras protein with water molecules identifies the potential role of switch II and P-loop. Comput Biol Med. 2021 08; 135:104597. PMID: 34237589.
      Citations:    
    36. Udhaya Kumar S, Madhana Priya N, Thirumal Kumar D, Anu Preethi V, Kumar V, Nagarajan D, Magesh R, Younes S, Zayed H, George Priya Doss C. An integrative analysis to distinguish between emphysema (EML) and alpha-1 antitrypsin deficiency-related emphysema (ADL)-A systems biology approach. Adv Protein Chem Struct Biol. 2021; 127:315-342. PMID: 34340772.
      Citations:    
    37. Kumar D T, Shaikh N, Kumar S U, Doss C GP, Zayed H. Structure-Based Virtual Screening to Identify Novel Potential Compound as an Alternative to Remdesivir to Overcome the RdRp Protein Mutations in SARS-CoV-2. Front Mol Biosci. 2021; 8:645216. PMID: 33898520; PMCID: PMC8062963.
      Citations:    
    38. Kumar SU, Priya NM, Nithya SR, Kannan P, Jain N, Kumar DT, Magesh R, Younes S, Zayed H, Doss CGP. A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing. 3 Biotech. 2021 Apr; 11(4):198. PMID: 33816047; PMCID: PMC8003899.
      Citations:    
    39. Udhaya Kumar S, Saleem A, Thirumal Kumar D, Anu Preethi V, Younes S, Zayed H, Tayubi IA, George Priya Doss C. A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis. Adv Protein Chem Struct Biol. 2021; 127:343-364. PMID: 34340773.
      Citations:    
    40. Kumar SU, Sankar S, Kumar DT, Younes S, Younes N, Siva R, Doss CGP, Zayed H. Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III. Cell Biochem Biophys. 2021 Jun; 79(2):201-219. PMID: 33555556.
      Citations:    
    41. Thirumal Kumar D, Udhaya Kumar S, Magesh R, George Priya Doss C. Investigating mutations at the hotspot position of the ERBB2 and screening for the novel lead compound to treat breast cancer - a computational approach. Adv Protein Chem Struct Biol. 2021; 123:49-71. PMID: 33485488.
      Citations:    
    42. Mishra S, Shah MI, Udhaya Kumar S, Thirumal Kumar D, Gopalakrishnan C, Al-Subaie AM, Magesh R, George Priya Doss C, Kamaraj B. Network analysis of transcriptomics data for the prediction and prioritization of membrane-associated biomarkers for idiopathic pulmonary fibrosis (IPF) by bioinformatics approach. Adv Protein Chem Struct Biol. 2021; 123:241-273. PMID: 33485486.
      Citations:    
    43. S UK, Sankar S, Younes S, D TK, Ahmad MN, Okashah SS, Kamaraj B, Al-Subaie AM, C GPD, Zayed H. Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach. Molecules. 2020 Nov 26; 25(23). PMID: 33255942; PMCID: PMC7730838.
      Citations:    
    44. S UK, Rajan B, D TK, V AP, Abunada T, Younes S, Okashah S, Ethiraj S, C GPD, Zayed H. Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity. Genes (Basel). 2020 10 25; 11(11). PMID: 33113859; PMCID: PMC7693799.
      Citations:    
    45. S UK, R B, D TK, Doss CGP, Zayed H. Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach. J Biomol Struct Dyn. 2022 03; 40(4):1571-1585. PMID: 33034275.
      Citations:    
    46. Udhaya Kumar S, Thirumal Kumar D, Bithia R, Sankar S, Magesh R, Sidenna M, George Priya Doss C, Zayed H. Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach. Front Genet. 2020; 11:734. PMID: 32760426; PMCID: PMC7373787.
      Citations:    
    47. Udhaya Kumar S, Thirumal Kumar D, Siva R, George Priya Doss C. Kerala, India's Front Runner in Novel Coronavirus Disease (COVID-19). Front Med (Lausanne). 2020; 7:355. PMID: 32714937; PMCID: PMC7343716.
      Citations:    
    48. Kumar SU, Kumar DT, Christopher BP, Doss CGP. The Rise and Impact of COVID-19 in India. Front Med (Lausanne). 2020; 7:250. PMID: 32574338; PMCID: PMC7256162.
      Citations:    
    49. Udhaya Kumar S, Thirumal Kumar D, Siva R, George Priya Doss C, Younes S, Younes N, Sidenna M, Zayed H. Dysregulation of Signaling Pathways Due to Differentially Expressed Genes From the B-Cell Transcriptomes of Systemic Lupus Erythematosus Patients - A Bioinformatics Approach. Front Bioeng Biotechnol. 2020; 8:276. PMID: 32426333; PMCID: PMC7203449.
      Citations:    
    50. D TK, Jain N, Kumar S U, Jena PP, Ramamoorthy S, Priya Doss C G, Zayed H. Molecular dynamics simulations to decipher the structural and functional consequences of pathogenic missense mutations in the galactosylceramidase (GALC) protein causing Krabbe's disease. J Biomol Struct Dyn. 2021 Mar; 39(5):1795-1810. PMID: 32186243.
      Citations:    
    51. Thirumal Kumar D, Udhaya Kumar S, Nishaat Laeeque AS, Apurva Abhay S, Bithia R, Magesh R, Kumar M, Zayed H, George Priya Doss C. Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder - Blau syndrome. Adv Protein Chem Struct Biol. 2020; 120:379-408. PMID: 32085886.
      Citations:    
    52. Udhaya Kumar S, Thirumal Kumar D, Mandal PD, Sankar S, Haldar R, Kamaraj B, Walter CEJ, Siva R, George Priya Doss C, Zayed H. Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene. Adv Protein Chem Struct Biol. 2020; 120:349-377. PMID: 32085885.
      Citations:    
    53. Thirumal Kumar D, Jain N, Udhaya Kumar S, George Priya Doss C, Zayed H. Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach. J Biomol Struct Dyn. 2021 Jan; 39(1):171-187. PMID: 31870226.
      Citations:    
    54. Kumar SU, Kumar DT, Siva R, Doss CGP, Zayed H. Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer. Front Bioeng Biotechnol. 2019; 7:391. PMID: 31921802; PMCID: PMC6927934.
      Citations:    
    55. Kumar S U, Kumar D T, R S, Doss C GP, Zayed H. An extensive computational approach to analyze and characterize the functional mutations in the galactose-1-phosphate uridyl transferase (GALT) protein responsible for classical galactosemia. Comput Biol Med. 2020 02; 117:103583. PMID: 32072977.
      Citations:    
    56. Jung J, Udhaya Kumar S, Choi I, Huh TL, Rhee M. Znf76 is associated with development of the eyes, midbrain, MHB, and hindbrain in zebrafish embryos. Anim Cells Syst (Seoul). 2019 Feb; 23(1):26-31. PMID: 30834156; PMCID: PMC6394295.
      Citations:    
    57. Mathew J, Jagadeesh SM, Bhat M, Udhaya Kumar S, Thiyagarajan S, Srinivasan S. Mutations in ARSB in MPS VI patients in India. Mol Genet Metab Rep. 2015 Sep; 4:53-61. PMID: 26937411; PMCID: PMC4750586.
      Citations:    
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