Rapamycin-Insensitive Companion of mTOR Protein
"Rapamycin-Insensitive Companion of mTOR Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An adaptor protein subunit of MTORC2 COMPLEX. It functions as a structural component and is phosphorylated by RIBOSOMAL PROTEIN S6 KINASES, integrating signals for cell growth and proliferation, especially during embryonic development.
| Descriptor ID |
D000076226
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| MeSH Number(s) |
D05.500.356.500 D08.811.913.696.620.682.700.931.750.500 D12.644.360.024.323 D12.776.157.057.156 D12.776.476.024.411 D12.776.476.925.750.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Rapamycin-Insensitive Companion of mTOR Protein".
Below are MeSH descriptors whose meaning is more specific than "Rapamycin-Insensitive Companion of mTOR Protein".
This graph shows the total number of publications written about "Rapamycin-Insensitive Companion of mTOR Protein" by people in this website by year, and whether "Rapamycin-Insensitive Companion of mTOR Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Rapamycin-Insensitive Companion of mTOR Protein" by people in Profiles.
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Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency. Nat Med. 2019 11; 25(11):1684-1690.
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Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. J Biol Chem. 2016 Jan 01; 291(1):198-214.
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FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway. Cancer Res. 2014 Mar 15; 74(6):1682-93.
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Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell. 2012 Sep 07; 11(3):415-28.
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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood. 2007 Apr 15; 109(8):3509-12.
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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006 Oct 06; 127(1):125-37.