Eukaryotic Initiation Factor-2
"Eukaryotic Initiation Factor-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Eukaryotic initiation factor of protein synthesis. In higher eukaryotes the factor consists of three subunits: alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP.
| Descriptor ID |
D015852
|
| MeSH Number(s) |
D12.776.835.725.868.249
|
| Concept/Terms |
Eukaryotic Initiation Factor-2- Eukaryotic Initiation Factor-2
- Eukaryotic Initiation Factor 2
- Initiation Factor-2, Eukaryotic
- Peptide Initiation Factor EIF-2
- Peptide Initiation Factor EIF 2
- Eukaryotic Peptide Initiation Factor-2
- Eukaryotic Peptide Initiation Factor 2
- EIF-2
- EIF 2
- EIF2
|
Below are MeSH descriptors whose meaning is more general than "Eukaryotic Initiation Factor-2".
Below are MeSH descriptors whose meaning is more specific than "Eukaryotic Initiation Factor-2".
This graph shows the total number of publications written about "Eukaryotic Initiation Factor-2" by people in this website by year, and whether "Eukaryotic Initiation Factor-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 2 | 3 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 2 | 1 | 3 |
| 2007 | 1 | 2 | 3 |
| 2008 | 1 | 2 | 3 |
| 2009 | 2 | 4 | 6 |
| 2010 | 0 | 1 | 1 |
| 2011 | 2 | 2 | 4 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 1 | 1 | 2 |
| 2016 | 4 | 0 | 4 |
| 2017 | 1 | 3 | 4 |
| 2018 | 2 | 3 | 5 |
| 2019 | 1 | 2 | 3 |
| 2020 | 2 | 2 | 4 |
| 2021 | 1 | 3 | 4 |
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Below are the most recent publications written about "Eukaryotic Initiation Factor-2" by people in Profiles.
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BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2a Phosphorylation. Gastroenterology. 2022 04; 162(4):1256-1271.e14.
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Sequencing of Argonaute-bound microRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a. PLoS Genet. 2021 12; 17(12):e1009934.
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Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells. Nat Commun. 2021 06 02; 12(1):3285.
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PERK-eIF2a-ERK1/2 axis drives mesenchymal-endothelial transition of cancer-associated fibroblasts in pancreatic cancer. Cancer Lett. 2021 09 01; 515:86-95.
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Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast-like Cells Is Driven by an Unfolded Protein Response. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):302-316.
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eIF2a controls memory consolidation via excitatory and somatostatin neurons. Nature. 2020 10; 586(7829):412-416.
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GADD34 is a modulator of autophagy during starvation. Sci Adv. 2020 09; 6(39).
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The integrated stress response: From mechanism to disease. Science. 2020 04 24; 368(6489).
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Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science. 2019 11 15; 366(6467):843-849.
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Translational Control in the Brain in Health and Disease. Cold Spring Harb Perspect Biol. 2019 08 01; 11(8).