Protein Inhibitors of Activated STAT
"Protein Inhibitors of Activated STAT" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally related proteins that are constitutively expressed and that negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. PIAS proteins inhibit the activity of signal transducers and activators of transcription.
| Descriptor ID |
D050828
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| MeSH Number(s) |
D12.644.360.024.319 D12.776.157.057.124 D12.776.476.024.402
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Inhibitors of Activated STAT".
Below are MeSH descriptors whose meaning is more specific than "Protein Inhibitors of Activated STAT".
This graph shows the total number of publications written about "Protein Inhibitors of Activated STAT" by people in this website by year, and whether "Protein Inhibitors of Activated STAT" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Inhibitors of Activated STAT" by people in Profiles.
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Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. Nat Commun. 2020 10 14; 11(1):5182.
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SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interacting Protein-1 in TGF-? Responses. J Biol Chem. 2016 Nov 18; 291(47):24418-24430.
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PIAS1 is a GATA4 SUMO ligase that regulates GATA4-dependent intestinal promoters independent of SUMO ligase activity and GATA4 sumoylation. PLoS One. 2012; 7(4):e35717.
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BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11294-9.
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Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation. J Biol Chem. 2007 Mar 02; 282(9):6517-24.
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Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1. J Biol Chem. 2004 May 28; 279(22):22857-65.
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Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3). Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):99-104.
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Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9791-6.
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Protein inhibitor of activated signal transducer and activator of transcription (STAT)-1 (PIAS-1) regulates the IFN-gamma response in macrophage cell lines. Cell Signal. 2002 Jun; 14(6):537-45.
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Adriamycin inhibits human RH II/Gu RNA helicase activity by binding to its substrate. Biochem Biophys Res Commun. 1999 Dec 20; 266(2):361-5.