Protein Inhibitors of Activated STAT
"Protein Inhibitors of Activated STAT" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally related proteins that are constitutively expressed and that negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. PIAS proteins inhibit the activity of signal transducers and activators of transcription.
| Descriptor ID |
D050828
|
| MeSH Number(s) |
D12.644.360.024.319 D12.776.157.057.124 D12.776.476.024.402
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Protein Inhibitors of Activated STAT".
Below are MeSH descriptors whose meaning is more specific than "Protein Inhibitors of Activated STAT".
This graph shows the total number of publications written about "Protein Inhibitors of Activated STAT" by people in this website by year, and whether "Protein Inhibitors of Activated STAT" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 2 | 0 | 2 |
| 2013 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2020 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Inhibitors of Activated STAT" by people in Profiles.
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Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy. FASEB J. 2022 11; 36(11):e22592.
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A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease. PLoS Genet. 2020 11; 16(11):e1009106.
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Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. Nat Commun. 2020 10 14; 11(1):5182.
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SUMO Modification Reverses Inhibitory Effects of Smad Nuclear Interacting Protein-1 in TGF-? Responses. J Biol Chem. 2016 Nov 18; 291(47):24418-24430.
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Multiple Functions of Protein Inhibitor of Activated STAT1 in Regulating Endothelial Cell Proliferation and Inflammation. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1717-9.
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Nutrient restriction of glucose or serum results in similar proteomic expression changes in 3D colon cancer cell cultures. Nutr Res. 2016 10; 36(10):1068-1080.
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ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure. Circ Cardiovasc Genet. 2015 Oct; 8(5):643-52.
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Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity. J Biol Chem. 2013 May 03; 288(18):12580-95.
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Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):321-9.
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Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation. PLoS One. 2012; 7(10):e48019.