Hepatocyte Nuclear Factor 4
"Hepatocyte Nuclear Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subfamily of nuclear receptors that regulate GENETIC TRANSCRIPTION of a diverse group of GENES involved in the synthesis of BLOOD COAGULATION FACTORS; and in GLUCOSE; CHOLESTEROL; and FATTY ACIDS metabolism.
| Descriptor ID |
D051557
|
| MeSH Number(s) |
D12.776.260.262.968 D12.776.660.352.968 D12.776.826.119 D12.776.930.318.968
|
| Concept/Terms |
Hepatocyte Nuclear Factor 4- Hepatocyte Nuclear Factor 4
- Hepatocyte Nuclear Factor-Forkhead Homolog 4
- Hepatocyte Nuclear Factor Forkhead Homolog 4
- HNF4 Transcription Factor
- Transcription Factor, HNF4
|
Below are MeSH descriptors whose meaning is more general than "Hepatocyte Nuclear Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Hepatocyte Nuclear Factor 4".
This graph shows the total number of publications written about "Hepatocyte Nuclear Factor 4" by people in this website by year, and whether "Hepatocyte Nuclear Factor 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 0 | 3 | 3 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2016 | 2 | 0 | 2 |
| 2017 | 0 | 2 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hepatocyte Nuclear Factor 4" by people in Profiles.
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HNF4a regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer. Nat Commun. 2020 08 07; 11(1):3978.
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Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nat Genet. 2019 10; 51(10):1459-1474.
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A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity. Nat Genet. 2019 05; 51(5):777-785.
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Incompatibility of the circadian protein BMAL1 and HNF4a in hepatocellular carcinoma. Nat Commun. 2018 10 19; 9(1):4349.
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Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. Inflamm Bowel Dis. 2018 01 18; 24(2):346-360.
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Monogenic diabetes in overweight and obese youth diagnosed with type 2 diabetes: the TODAY clinical trial. Genet Med. 2018 06; 20(6):583-590.
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Mir-338-3p Mediates Tnf-A-Induced Hepatic Insulin Resistance by Targeting PP4r1 to Regulate PP4 Expression. Cell Physiol Biochem. 2017; 41(6):2419-2431.
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Hepatocyte nuclear factor 4a is required for cell differentiation and homeostasis in the adult mouse gastric epithelium. Am J Physiol Gastrointest Liver Physiol. 2016 08 01; 311(2):G267-75.
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Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4a (HNF4?) Is Vital to Beta-cell Function. J Biol Chem. 2016 Mar 18; 291(12):6146-57.
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HNF4a is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer. Gut. 2016 Jan; 65(1):19-32.