Mismatch Repair Endonuclease PMS2
"Mismatch Repair Endonuclease PMS2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.
| Descriptor ID |
D000070976
|
| MeSH Number(s) |
D08.811.074.766.250 D08.811.277.040.025.215.250 D08.811.277.352.335.350.600 D12.776.260.540.250
|
| Concept/Terms |
Mismatch Repair Endonuclease PMS2- Mismatch Repair Endonuclease PMS2
- PMS1 Homolog 2, Mismatch Repair Protein
- PMS2 Protein
- Postmeiotic Segregation Increased-S. cerevisiae-2
- Postmeiotic Segregation Increased S. cerevisiae 2
- PMS-2 Protein
- PMS 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Mismatch Repair Endonuclease PMS2".
Below are MeSH descriptors whose meaning is more specific than "Mismatch Repair Endonuclease PMS2".
This graph shows the total number of publications written about "Mismatch Repair Endonuclease PMS2" by people in this website by year, and whether "Mismatch Repair Endonuclease PMS2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mismatch Repair Endonuclease PMS2" by people in Profiles.
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Increased colorectal and endometrial cancer rates in a genomically ascertained Lynch syndrome cohort. JNCI Cancer Spectr. 2025 Jul 01; 9(4).
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DNA mismatch repair defect and intratumor heterogeneous deficiency differently impact immune responses in diffuse large B-cell lymphoma. Oncoimmunology. 2024; 13(1):2384667.
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A validation of models for prediction of pathogenic variants in mismatch repair genes. Genet Med. 2022 10; 24(10):2155-2166.
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Mismatch repair protein loss in breast cancer: clinicopathological associations in a large British Columbia cohort. Breast Cancer Res Treat. 2020 Jan; 179(1):3-10.
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Clinical Management and Tumor Surveillance Recommendations of Inherited Mismatch Repair Deficiency in Childhood. Clin Cancer Res. 2017 Jun 01; 23(11):e32-e37.
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A Comprehensive Strategy for Accurate Mutation Detection of the Highly Homologous PMS2. J Mol Diagn. 2015 Sep; 17(5):545-53.
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PMS2 monoallelic mutation carriers: the known unknown. Genet Med. 2016 Jan; 18(1):13-9.
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Simultaneous colonic adenocarcinoma and medulloblastoma in a 12-year-old with biallelic deletions in PMS2. J Pediatr. 2013 Aug; 163(2):601-3.
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Functional residues on the surface of the N-terminal domain of yeast Pms1. DNA Repair (Amst). 2010 Apr 04; 9(4):448-57.
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Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells. DNA Repair (Amst). 2009 Aug 06; 8(8):878-85.