Mismatch Repair Endonuclease PMS2
"Mismatch Repair Endonuclease PMS2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.
| Descriptor ID |
D000070976
|
| MeSH Number(s) |
D08.811.074.766.250 D08.811.277.040.025.215.250 D08.811.277.352.335.350.600 D12.776.260.540.250
|
| Concept/Terms |
Mismatch Repair Endonuclease PMS2- Mismatch Repair Endonuclease PMS2
- PMS1 Homolog 2, Mismatch Repair Protein
- PMS2 Protein
- Postmeiotic Segregation Increased-S. cerevisiae-2
- Postmeiotic Segregation Increased S. cerevisiae 2
- PMS-2 Protein
- PMS 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Mismatch Repair Endonuclease PMS2".
Below are MeSH descriptors whose meaning is more specific than "Mismatch Repair Endonuclease PMS2".
This graph shows the total number of publications written about "Mismatch Repair Endonuclease PMS2" by people in this website by year, and whether "Mismatch Repair Endonuclease PMS2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Mismatch Repair Endonuclease PMS2" by people in Profiles.
-
DNA mismatch repair defect and intratumor heterogeneous deficiency differently impact immune responses in diffuse large B-cell lymphoma. Oncoimmunology. 2024; 13(1):2384667.
-
Simultaneous colonic adenocarcinoma and medulloblastoma in a 12-year-old with biallelic deletions in PMS2. J Pediatr. 2013 Aug; 163(2):601-3.
-
Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells. DNA Repair (Amst). 2009 Aug 06; 8(8):878-85.
-
ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. Mol Cell Biol. 2004 Jul; 24(14):6430-44.
-
Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. Pathobiology. 1997; 65(6):293-300.
-
Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature. 1994 Sep 01; 371(6492):75-80.